Evidence map›Paper›PMID 35022931›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2022

Arterial intracranial thrombosis as the first manifestation of vaccine-induced immune thrombotic thrombocytopenia (VITT): a case report.

Michelangelo Mancuso, Dario Luca Lauretti, Nadia Cecconi, Massimo Santini, Valentina Lami, Giovanni Orlandi, Sergio Casagli, Antonella Ghetta, Gaetano Liberti, Benini Maria Elena and 2 more

Open access · bronzeAbstract readCase Reports
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Ocular motility disorders following coronavirus disease-19 vaccination.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023
    Article
  6. Co-VAN study: COVID-19 vaccine associated neurological diseases- an experience from an apex neurosciences centre and review of the literature.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2023
    Review
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Michelangelo Mancuso *Department of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Pisa, Italy. michelangelo.mancuso@unipi.it.ORCID http://orcid.org/0000-0003-2738-8562
Dario Luca Lauretti *Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Nadia CecconiClinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Massimo SantiniU.O. Medicina D'Urgenza E Pronto Soccorso, Emergency Department, Nuovo Santa Chiara Hospital, Azienda Ospedaliero-Universitaria of Pisa, Pisa, Italy.
Valentina LamiU.O. Medicina D'Urgenza E Pronto Soccorso, Emergency Department, Nuovo Santa Chiara Hospital, Azienda Ospedaliero-Universitaria of Pisa, Pisa, Italy.
Giovanni OrlandiDepartment of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Pisa, Italy.
Sergio CasagliNeuroanestesia E Rianimazione, Nuovo Santa Chiara Hospital, Azienda Ospedaliero-Universitaria of Pisa, Pisa, Italy.
Antonella GhettaNeuroanestesia E Rianimazione, Nuovo Santa Chiara Hospital, Azienda Ospedaliero-Universitaria of Pisa, Pisa, Italy.
Gaetano LibertiNeurosurgery Unit, Azienda Ospedaliero-Universitaria of Pisa, Pisa, Italy.
Benini Maria ElenaNeurosurgery Unit, Azienda Ospedaliero-Universitaria of Pisa, Pisa, Italy.
Gabriele SicilianoDepartment of Clinical and Experimental Medicine, Neurological Clinic, University of Pisa, Pisa, Italy.
Mirco CosottiniDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
Azienda Ospedaliera Universitaria Pisana · ITUniversity of Pisa · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveWe describe a severe case of vaccine-induced immune thrombotic thrombocytopenia (VITT) after the first dose of the ChAdOx1 nCoV-19 vaccine leading to massive ischemic stroke.

methodsA 42-year-old woman developed acute left hemiparesis (NIHSS 12) 9 days after the first vaccine dose.

resultsThe blood tests revealed low platelets (70 10 DISCUSSION: Healthcare providers should be aware of the possibility of ischemic stroke as a manifestation of VITT. Awareness on this very rare and possibly fatal complication should be reinforced on both the vaccine recipients and general practitioners.

Indexed as

COVID-19Intracranial ThrombosisThrombocytopeniaVaccinesAdultChAdOx1 nCoV-19COVID-19 VaccinesFemaleHumansChAdOx1 nCoV-19COVID-19 VaccinesVaccinesCOVID-19StrokeThrombocytopeniaVaccineVITT

Identifiers

PMID35022931
PMCPMC8754523
OpenAlexW4205284092

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.