Evidence map›Paper›PMID 35022875›Full record

ReviewEuropean journal of applied physiology2022

The impact of different forms of exercise on circulating endothelial progenitor cells in cardiovascular and metabolic disease.

Panagiotis Ferentinos, Costas Tsakirides, Michelle Swainson, Adam Davison, Marrissa Martyn-St James, Theocharis Ispoglou

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in European journal of applied physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Panagiotis FerentinosCarnegie School of Sport, Leeds Beckett University, Leeds, UK.
Costas TsakiridesCarnegie School of Sport, Leeds Beckett University, Leeds, UK.
Michelle SwainsonLancaster Medical School, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
Adam DavisonFlow Cytometry Facility, Leeds Institute of Cancer and Pathology St James's University Hospital, University of Leeds, Leeds, UK.
Marrissa Martyn-St JamesSchool of Health and Related Research, University of Sheffield, Sheffield, UK.
Theocharis IspoglouCarnegie School of Sport, Leeds Beckett University, Leeds, UK. t.ispoglou@leedsbeckett.ac.uk.ORCID http://orcid.org/0000-0002-7608-6512
Leeds Beckett University · GBLancaster University · GBUniversity of Leeds · GBUniversity of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circulating endothelial progenitor cells (EPCs) contribute to vascular repair and their monitoring could have prognostic clinical value. Exercise is often prescribed for the management of cardiometabolic diseases, however, it is not fully understood how it regulates EPCs.

objectivesto systematically examine the acute and chronic effects of different exercise modalities on circulating EPCs in patients with cardiovascular and metabolic disease.

methodsPreferred Reporting Items for Systematic Reviews and Meta-analyses guidelines were followed.

resultssix electronic databases and reference lists of eligible studies were searched to April 2021. Thirty-six trials met the inclusion criteria including 1731 participants. Acute trials: in chronic heart failure (CHF), EPC mobilisation was acutely increased after high intensity interval or moderate intensity continuous exercise training, while findings were inconclusive after a cardiopulmonary cycling exercise test. Maximal exercise tests acutely increased EPCs in ischaemic or revascularized coronary artery disease (CAD) patients. In peripheral arterial disease (PAD), EPC levels increased up to 24 h post-exercise. In patients with compromised metabolic health, EPC mobilisation was blunted after a single exercise session. Chronic trials: in CHF and acute coronary syndrome, moderate intensity continuous protocols, with or without resistance exercise or calisthenics, increased EPCs irrespective of EPC identification phenotype. Findings were equivocal in CAD regardless of exercise mode, while in severe PAD disease EPCs increased. High intensity interval training increased EPCs in hypertensive metabolic syndrome and heart failure reduced ejection fraction.

conclusionthe clinical condition and exercise modality influence the degree of EPC mobilisation and magnitude of EPC increases in the long term.

Indexed as

Endothelial Progenitor CellsMetabolic DiseasesEndothelium, VascularExerciseHumansStroke VolumeAerobic trainingCardiometabolic healthCardiovascular diseaseEndothelial progenitor cellsEPC mobilisationExerciseFlow cytometryHigh intensity interval trainingModerate intensity continuous trainingResistance exerciseVascular health

Identifiers

PMID35022875
PMCPMC8927049
OpenAlexW4206118561

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.