Evidence map›Paper›PMID 35022828›Full record

ArticleWorld journal of urology2022

Predicting GFR after radical nephrectomy: the importance of split renal function.

Nityam Rathi, Diego A Palacios, Emily Abramczyk, Hajime Tanaka, Yunlin Ye, Jianbo Li, Yosuke Yasuda, Robert Abouassaly, Mohamed Eltemamy, Alvin Wee and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in World journal of urology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 3 countries.

Nityam RathiCenter for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, Room Q10-120, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Diego A PalaciosCenter for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, Room Q10-120, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Emily AbramczykCenter for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, Room Q10-120, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Hajime TanakaCenter for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, Room Q10-120, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Yunlin YeCenter for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, Room Q10-120, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Jianbo LiDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Yosuke YasudaCenter for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, Room Q10-120, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Robert AbouassalyCenter for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, Room Q10-120, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Mohamed EltemamyCenter for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, Room Q10-120, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Alvin WeeCenter for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, Room Q10-120, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Christopher WeightCenter for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, Room Q10-120, 9500 Euclid Avenue, Cleveland, OH, 44195, USA.
Steven C CampbellCenter for Urologic Oncology, Glickman Urological and Kidney Institute, Cleveland Clinic, Room Q10-120, 9500 Euclid Avenue, Cleveland, OH, 44195, USA. campbes3@ccf.org.ORCID http://orcid.org/0000-0002-9110-0343
Cleveland Clinic · USTokyo Medical and Dental University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate a conceptually simple model to predict new-baseline-glomerular-filtration-rate (NBGFR) after radical nephrectomy (RN) based on split-renal-function (SRF) and renal-functional-compensation (RFC), and to compare its predictive accuracy against a validated non-SRF-based model. RN should only be considered when the tumor has increased oncologic potential and/or when there is concern about perioperative morbidity with PN due to increased tumor complexity. In these circumstances, accurate prediction of NBGFR after RN can be important, with a threshold NBGFR > 45 ml/min/1.73m

methods236 RCC patients who underwent RN (2010-2012) with preoperative imaging (CT/MRI) and relevant functional data were included. NBGFR was defined as GFR 3-12 months post-RN. SRF was determined using semi-automated software that provides differential parenchymal-volume-analysis (PVA) from preoperative imaging. Our SRF-based model was: Predicted NBGFR = 1.24 (× Global GFR

resultsThe correlation-coefficients (r) were 0.87/0.72 for SRF-based/non-SRF-based models, respectively (p = 0.005). For prediction of NBGFR > 45 ml/min/1.73m

conclusionPrevious non-SRF-based models to predict NBGFR post-RN are complex and omit two important parameters: SRF and RFC. Our proposed model prioritizes these parameters and provides a conceptually simple, accurate, and clinically implementable approach to predict NBGFR post-RN. SRF can be easily obtained using PVA software that is affordable, readily available (FUJIFILM-Medical-Systems), and more accurate than nuclear-renal-scans. The SRF-based model demonstrates greater predictive-accuracy than a non-SRF-based model, including the clinically-important predictive-threshold of NBGFR > 45 ml/min/1.73m

Indexed as

Carcinoma, Renal CellKidney NeoplasmsGlomerular Filtration RateHumansKidneyNephrectomyRetrospective StudiesFunctional compensationKidney cancerParenchymal volume analysisRadical nephrectomySplit renal function

Identifiers

PMID35022828
OpenAlexW4205877715

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.