ArticlePediatrics2022
Delivery Characteristics and the Risk of Early-Onset Neonatal Sepsis.
Article in Pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 31 citations in OpenAlex.
- Long-term sustainability and safety of a delivery-based early-onset sepsis evaluation strategy for very low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Association between initial empirical antibiotic therapy and necrotizing enterocolitis in very preterm infants at different risk for early-onset sepsis: a multicenter cohort study.BMC pregnancy and childbirth · 2026Observational
- Differential roles of interleukin-6 and adrenomedullin in early diagnosis and mortality predictions in late-onset neonatal sepsis.Clinical and experimental pediatrics · 2025Article
- Understanding variation in management of early-onset neonatal sepsis in India: a vignette-based survey.BMJ paediatrics open · 2025Article
- Distribution of Pathogenic Bacteria in Health Care Associated Sepsis in Preterm Infants and Ten Years Variation in Their Drug Resistance.Infection and drug resistance · 2025Article
- Infants Born at Late Preterm Gestation: Management during the Birth Hospitalization.The Journal of pediatrics · 2025Article
- Association between tumor necrosis factor-α gene polymorphism and interleukin-6 level with mortality of neonatal sepsis.Narra J · 2024Article
- Alteration of Maternal Serum Ferritin in Pregnancy and Maternal-fetal Infections: A retrospective cohort study.Pakistan journal of medical sciences · 2024Article
- Maternal and neonatal IgG againstmedRxiv : the preprint server for health sciences · 2024Article
- Utility of the Neonatal Early-Onset Sepsis Calculator in a Low-Risk Population.American journal of perinatology · 2024Article
- Maternal and neonatal IgG against Klebsiella pneumoniae are associated with lower risk of neonatal sepsis: A case-control study of hospitalized neonates in Botswana.PLOS global public health · 2024Article
- Retrospective analysis of pediatric sepsis and the burden of antimicrobial resistance in Duhok, Kurdistan Region of Iraq.Frontiers in pharmacology · 2024Article
- Antibiotic Use for Sepsis in Hospitalized Neonates in Botswana: Factors Associated with Guideline-Divergent Prescribing.Microorganisms · 2023Article
- Association of delivery risk phenotype with early-onset sepsis in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Early antibiotic exposure in very-low birth weight infants and infection risk at 3-7 days after birth.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- Preterm infants at low risk for early-onset sepsis differ in early fecal microbiome assembly.Gut microbesArticle
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7 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesMultiple strategies are used to identify newborn infants at high risk of culture-confirmed early-onset sepsis (EOS). Delivery characteristics have been used to identify preterm infants at lowest risk of infection to guide initiation of empirical antibiotics. Our objectives were to identify term and preterm infants at lowest risk of EOS using delivery characteristics and to determine antibiotic use among them.
methodsThis was a retrospective cohort study of term and preterm infants born January 1, 2009 to December 31, 2014, with blood culture with or without cerebrospinal fluid culture obtained ≤72 hours after birth. Criteria for determining low EOS risk included: cesarean delivery, without labor or membrane rupture before delivery, and no antepartum concern for intraamniotic infection or nonreassuring fetal status. We determined the association between these characteristics, incidence of EOS, and antibiotic duration among infants without EOS.
resultsAmong 53 575 births, 7549 infants (14.1%) were evaluated and 41 (0.5%) of those evaluated had EOS. Low-risk delivery characteristics were present for 1121 (14.8%) evaluated infants, and none had EOS. Whereas antibiotics were initiated in a lower proportion of these infants (80.4% vs 91.0%, P < .001), duration of antibiotics administered to infants born with and without low-risk characteristics was not different (adjusted difference 0.6 hours, 95% CI [-3.8, 5.1]).
conclusionsRisk of EOS among infants with low-risk delivery characteristics is extremely low. Despite this, a substantial proportion of these infants are administered antibiotics. Delivery characteristics should inform empirical antibiotic management decisions among infants born at all gestational ages.
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