Evidence map›Paper›PMID 35022740›Full record

ArticleThe Journal of infectious diseases2022

Relationship Between Anxiety, Depression, and Susceptibility to Severe Acute Respiratory Syndrome Coronavirus 2 Infection: Proof of Concept.

Kavita Vedhara, Kieran Ayling, Ru Jia, Lucy Fairclough, Joanne R Morling, Jonathan K Ball, Holly Knight, Holly Blake, Jessica Corner, Chris Denning and 4 more

Abstract read
In one paragraph

Article in The Journal of infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Psychology Meets Biology in COVID-19: What We Know and Why It Matters for Public Health.Policy insights from the behavioral and brain sciences · 2023
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Kavita VedharaSchool of Medicine, University of Nottingham, Nottingham, United Kingdom.ORCID 0000-0002-9940-7534
Kieran AylingSchool of Medicine, University of Nottingham, Nottingham, United Kingdom.ORCID 0000-0003-1766-8800
Ru JiaSchool of Medicine, University of Nottingham, Nottingham, United Kingdom.
Lucy FaircloughSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Joanne R MorlingSchool of Medicine, University of Nottingham, Nottingham, United Kingdom.
Jonathan K BallSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Holly KnightSchool of Medicine, University of Nottingham, Nottingham, United Kingdom.
Holly BlakeNIHR Nottingham Biomedical Research Centre, University of Nottingham, Nottingham, United Kingdom.
Jessica CornerUniversity Executive Board, University of Nottingham, Nottingham, United Kingdom.
Chris DenningBiodiscovery Institute, University of Nottingham, Nottingham, United Kingdom.ORCID 0000-0003-0802-8617
Kirsty BoltonSchool of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom.
Hannah JacksonSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.
Carol CouplandSchool of Medicine, University of Nottingham, Nottingham, United Kingdom.
Patrick TigheSchool of Life Sciences, University of Nottingham, Nottingham, United Kingdom.

Funding

Medical Research Council MC_PC_20027Medical Research Council MR/P008348/1
6 · The paper itself

Abstract

backgroundPsychological factors can influence susceptibility to viral infections. We examined whether such influences are evident in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

methodsParticipants (n = 102) completed measures of anxiety, depression, positive mood, and loneliness and provided a blood sample for the measurement of antibodies to the SARS-CoV-2 spike and nucleocapsid proteins.

resultsSARS-CoV-2 was significantly negatively associated with anxiety and depression. The model remained significant after adjustment for age and gender, although anxiety and depression were no longer significant independent predictors.

conclusionsThese findings offer early support for the hypothesis that psychological factors may influence susceptibility to SARS-CoV-2 infection.

Indexed as

COVID-19Antibodies, ViralAnxietyDepressionHumansNucleocapsid ProteinsSARS-CoV-2Spike Glycoprotein, CoronavirusAntibodies, ViralNucleocapsid ProteinsSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2antibodiesanxietyCOVID-19depressionSARS-CoV-2

Identifiers

PMID35022740
PMCPMC8807218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.