Evidence map›Paper›PMID 35022609›Full record

ArticleNature2022

Mutation bias reflects natural selection in Arabidopsis thaliana.

J Grey Monroe, Thanvi Srikant, Pablo Carbonell-Bejerano, Claude Becker, Mariele Lensink, Moises Exposito-Alonso, Marie Klein, Julia Hildebrandt, Manuela Neumann, Daniel Kliebenstein and 6 more

Erratum issuedAbstract read
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 184 papers.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

184 citing papers in PubMed.

  1. Aspects of plant intelligence (ii).Plant signaling & behavior · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. A sorghum-anchored pan-grass syntenic gene set in grasses.NAR genomics and bioinformatics · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Genome degradation in plant tissue culture.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Horticulture research · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Article

124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

J Grey MonroeDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, Germany. gmonroe@ucdavis.edu.ORCID http://orcid.org/0000-0002-4025-5572
Thanvi SrikantDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, Germany.
Pablo Carbonell-BejeranoDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0002-7266-9665
Claude BeckerDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, Germany.
Mariele LensinkDepartment of Plant Sciences, University of California Davis, Davis, CA, USA.
Moises Exposito-AlonsoDepartment of Plant Biology, Carnegie Institution for Science, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5711-0700
Marie KleinDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, Germany.
Julia HildebrandtDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, Germany.
Manuela NeumannDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, Germany.ORCID http://orcid.org/0000-0003-2778-3028
Daniel KliebensteinDepartment of Plant Sciences, University of California Davis, Davis, CA, USA.ORCID http://orcid.org/0000-0001-5759-3175
Mao-Lun WengDepartment of Biology, Westfield State University, Westfield, MA, USA.
Eric ImbertISEM, University of Montpellier, Montpellier, France.ORCID http://orcid.org/0000-0001-9158-0925
Jon ÅgrenDepartment of Ecology and Genetics, EBC, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-9573-2463
Matthew T RutterDepartment of Biology, College of Charleston, Charleston, SC, USA.
Charles B FensterOak Lake Field Station, South Dakota State University, Brookings, SD, USA.
Detlef WeigelDepartment of Molecular Biology, Max Planck Institute for Biology Tübingen, Tübingen, Germany. weigel@weigelworld.org.ORCID http://orcid.org/0000-0002-2114-7963

Funding

Predicting and controlling polygenic health traits using probabilistic models and evolution-inspired gene editingDP5OD029506 · OD · UNIVERSITY OF CALIFORNIA BERKELEY · PI EXPOSITO-ALONSO, MOISES · 2020 to 2024
$2.0M
NIH HHS DP5 OD029506
6 · The paper itself

Abstract

Since the first half of the twentieth century, evolutionary theory has been dominated by the idea that mutations occur randomly with respect to their consequences

Indexed as

Evolution, MolecularModels, GeneticMutagenesisMutationArabidopsisEpigenomeEpigenomicsGene FrequencyGenes, EssentialGenes, PlantGenome, PlantMutation RatePolymorphism, GeneticSelection, Genetic

Identifiers

PMID35022609
PMCPMC8810380

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.