ArticleScientific reports2022
Aging-related cerebral microvascular changes visualized using ultrasound localization microscopy in the living mouse.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 105 citations in OpenAlex.
- Pancreatic Steatosis: Innocent Bystander or Silent Culprit?The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2026Article
- Ultrasound localisation microscopy tracks testicular microvascular adaptations to endocrine function in male infertility.EBioMedicine · 2026Article
- Noninvasive whole-brain imaging of glymphatic dynamics.Science advances · 2026Article
- Clinically translatable ultrasound localization microscopy reveals cerebrovascular remodelling and prognosis in patients with traumatic brain injury.Nature biomedical engineering · 2026Article
- Three-dimensional microangiography of the mouse brain using super-resolution ultrasound and optoacoustic imaging with a spherical array transducer.Photoacoustics · 2026Article
- Optical coherence tomography angiography reveals structural and hemodynamic remodeling of cerebral penetrating vessels owing to aging.Biomedical optics express · 2026Article
- Non-invasive characterization of pericyte dysfunction in mouse brain using functional ultrasound localization microscopy.Nature biomedical engineering · 2026Article
- Super-resolution ultrasound imaging indirectly reveals neurovascular uncoupling in substantia nigra of a Parkinson's disease model.NPJ Parkinson's disease · 2026Article
- A Minimally Invasive Framework Reveals Region-Specific Cerebrovascular Remodeling in Aging Using Intravital Functional Ultrasound Imaging and Ultrasound Localization Microscopy (fUS-ULM).Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Regional brain and cerebrovasculature morphology during normative aging in male and female C57BL/6N mice.Frontiers in aging neuroscience · 2026Article
- Article
- Imaging the brain by traversing the skull with light and sound.Nature biomedical engineering · 2025Review
- Ultrafast ultrasound localization microscopy for differential diagnosis of reactive hyperplasia and metastatic cervical lymph nodes: a pilot study.Quantitative imaging in medicine and surgery · 2025Article
- Impact of Aging and Light Stimulation Parameters on Retinal Hyperemia Responses in Functional Optical Coherence Tomography Angiography.Investigative ophthalmology & visual science · 2025Article
- Ultrasound matrix imaging for 3D transcranial in vivo localization microscopy.Science advances · 2025Article
- Progresses and clinical application of super-resolution ultrasound imaging: a narrative review.The ultrasound journal · 2025Review
- Cerebral blood flow and energy demand: imaging insights into neurovascular function.Neurophotonics · 2025Review
- Microstructural and microvascular features of white matter hyperintensities and their association with small vessel disease markers.Scientific reports · 2025Article
- OptimizingPhysics in medicine and biology · 2025Article
- Reduced removal of waste products from energy metabolism takes center stage in human brain aging.Scientific reports · 2025Article
6 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
Abstract
Aging-related cognitive decline is an emerging health crisis; however, no established unifying mechanism has been identified for the cognitive impairments seen in an aging population. A vascular hypothesis of cognitive decline has been proposed but is difficult to test given the requirement of high-fidelity microvascular imaging resolution with a broad and deep brain imaging field of view, which is restricted by the fundamental trade-off of imaging penetration depth and resolution. Super-resolution ultrasound localization microscopy (ULM) offers a potential solution by exploiting circulating microbubbles to achieve a vascular resolution approaching the capillary scale without sacrificing imaging depth. In this report, we apply ULM imaging to a mouse model of aging and quantify differences in cerebral vascularity, blood velocity, and vessel tortuosity across several brain regions. We found significant decreases in blood velocity, and significant increases in vascular tortuosity, across all brain regions in the aged cohort, and significant decreases in blood volume in the cerebral cortex. These data provide the first-ever ULM measurements of subcortical microvascular dynamics in vivo within the context of the aging brain and reveal that aging has a major impact on these measurements.
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