ArticleNature communications2022
Dynamic targeting enables domain-general inhibitory control over action and thought by the prefrontal cortex.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.
- Psychotherapy and inhibitory control: Insights from fMRI research.Psychiatry and clinical neurosciences · 2026Pooled it
- Inhibitory control deficits in borderline personality disorder: a meta-analysis of stop-signal and Go/No-Go tasks.Psychological medicine · 2025Pooled it
- Neural Correlates of Inhibitory Control in Impulsivity Traits in Non-Ecological Human-Computer Tasks: An ALE Meta-Analysis.Brain sciences · 2026Review
- Universal rhythmic architecture uncovers two modes of neural dynamics.Nature communications · 2026Article
- Distinct neural substrates of obsessions and compulsions in adolescent obsessive compulsive disorder.Translational psychiatry · 2026Article
- A cortico-subthalamic circuit rapidly engages and releases inhibition of specific movements depending on the environmental context.PLoS biology · 2026Article
- Sensitivity analysis enlightens effects of connectivity in a Neural Mass Model under Control-Target mode.PLoS computational biology · 2026Article
- Neural Reinstatement of Encoding Context Mediates the Switch between Fear and Extinction Recall.Journal of cognitive neuroscience · 2026Article
- Whole-Brain Dynamic Causal Tractography Atlas of Auditory and Visual Speech Networks Derived From Intracranial Neurophysiologic Data.Neurology · 2026Observational
- Cortico-basal ganglia dynamics of global and selective response inhibition in humans.bioRxiv : the preprint server for biology · 2026Article
- Prefrontal and Cerebellar Contributions to Semantic Memory Retrieval.Neurobiology of language (Cambridge, Mass.) · 2026Article
- The effectiveness and adaptiveness of suppressing unwanted thoughts.Psychonomic bulletin & review · 2025Review
- Neural signatures and personalized neuromodulation in a subject experiencing context-dependent inhibitory control deficits.NeuroImage · 2025Article
- Maintenance suppression enhances subsequent associative learning.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Pupil Fluctuations Signal Intentional Forgetting of Natural Scenes.Psychophysiology · 2025Article
- Parietal cortex is recruited by frontal and cingulate areas to support action monitoring and updating during stopping.NeuroImage · 2025Article
- Brain mechanisms underlying the inhibitory control of thought.Nature reviews. Neuroscience · 2025Review
- Hierarchical Organization of Bilateral Prefrontal-Basal Ganglia Circuits for Response Inhibition Control.Human brain mapping · 2025Article
- Trauma-analogue symptom variability predicted by inhibitory control and peritraumatic heart rate.Scientific reports · 2025Article
- Memory control deficits in the sleep-deprived human brain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
Abstract
Over the last two decades, inhibitory control has featured prominently in accounts of how humans and other organisms regulate their behaviour and thought. Previous work on how the brain stops actions and thoughts, however, has emphasised distinct prefrontal regions supporting these functions, suggesting domain-specific mechanisms. Here we show that stopping actions and thoughts recruits common regions in the right dorsolateral and ventrolateral prefrontal cortex to suppress diverse content, via dynamic targeting. Within each region, classifiers trained to distinguish action-stopping from action-execution also identify when people are suppressing their thoughts (and vice versa). Effective connectivity analysis reveals that both prefrontal regions contribute to action and thought stopping by targeting the motor cortex or the hippocampus, depending on the goal, to suppress their task-specific activity. These findings support the existence of a domain-general system that underlies inhibitory control and establish Dynamic Targeting as a mechanism enabling this ability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.