ArticleScientific reports2022
Association of red blood cell and platelet transfusions with persistent inflammation, immunosuppression, and catabolism syndrome in critically ill patients.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 19 citations in OpenAlex.
- Risk factors, biomarkers, and mechanisms for persistent inflammation, immunosuppression, and catabolism syndrome (PICS): a systematic review and meta-analysis.British journal of anaesthesia · 2024Pooled it
- Inhibition of red blood cell-derived small extracellular vesicles release by calpeptin attenuates neutrophil inflammation.Scientific reports · 2026Article
- Early Prediction and Prognostic Value of Chronic Critical Illness and Persistent Inflammation, Immunosuppression, and Catabolism Syndrome in Patients with Severe Acute Pancreatitis: A Retrospective Cohort Study.Journal of clinical medicine · 2026Article
- A Nomogram for Early Prediction of Inflammation, Catabolism, and Immunosuppression Syndrome in Critically Ill Patients.Diagnostics (Basel, Switzerland) · 2026Article
- Molecular Mechanisms of Transfusion-Associated Immunomodulation and Its Impact in the Critically Ill.International journal of molecular sciences · 2025Review
- The effect of allogeneic blood transfusion on burn mortality in a resource-limited setting.Burns : journal of the International Society for Burn Injuries · 2025Article
- Exploring the Relationship Between Blood Transfusions and Development of Bronchopulmonary Dysplasia in Neonates.Cureus · 2025Article
- The number of blood transfusions received and the incidence and severity of chronic lung disease among NICU patients born >31 weeks gestation.Journal of perinatology : official journal of the California Perinatal Association · 2025Article
- Predictors for prolonged and escalated perioperative antibiotic therapy after microvascular head and neck reconstruction: a comprehensive analysis of 446 cases.Head & face medicine · 2024Article
- Nano fuzzy alarming system for blood transfusion requirement detection in cancer using deep learning.Scientific reports · 2024Article
- Transfusion and Mortality in Acute Care Surgical Patients in Malawi: A Propensity-Matched Analysis.The Journal of surgical research · 2024Article
- Perioperative factors associated with survival following surgery for pancreatic cancer - a nationwide analysis of 473 cases from Denmark.BMC surgery · 2024Article
- Perioperative Risk Factors for Postoperative Pulmonary Complications After Minimally Invasive Esophagectomy.International journal of general medicine · 2024Article
- Anemia Recovery after Trauma: A Longitudinal Study.Surgical infections · 2023Article
- Transfusion of female blood in a rat model is associated with red blood cells entrapment in organs.PloS one · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this single-center retrospective cohort study was to investigate the relationship between blood transfusion and persistent inflammation, immunosuppression, and catabolism syndrome (PIICS). The study was conducted at the Critical Care Center at Toho University Omori Medical Center, Japan. We included 391 patients in the PIICS group (hospitalization for > 15 days, C-reactive protein > 3.0 mg/dL or albumin < 3.0 mg/dL or lymph < 800/μL on day 14) and 762 patients in the non-PIICS group (hospitalization for > 15 days and not meeting the PIICS criteria). We performed univariate and multivariate logistic regression analyses using PIICS as the objective variable and red blood cell (RBC) or fresh frozen plasma or platelet (PLT) transfusion and other confounding factors as explanatory variables. In addition, we conducted a sensitivity analysis using propensity score matching analysis. The multivariate and propensity score analyses showed that RBC and PLT transfusions were significantly associated with PIICS. This is the first study to report an association between RBC and PLT transfusions and PIICS. Our findings have contributed to better understanding the risk factors of PIICS and suggest that physicians should consider the risk of PIICS occurrence when administering blood transfusions in intensive care unit (ICU) patients.
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