Evidence map›Paper›PMID 35022325›Full record

ArticleGenes & development2022

Guide RNA acrobatics: the one-for-two shuffle.

U Thomas Meier

Abstract readComment
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

U Thomas MeierDepartment of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.ORCID 0000-0001-6677-2677

Funding

Cellular impact of X-linked dyskeratosis congenitaR01HL136662 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MEIER, U THOMAS · 2017 to 2020
$2.4M
NHLBI NIH HHS R01 HL136662
6 · The paper itself

Abstract

RNA modifications are crucial for the proper function of the RNAs. The sites of pseudouridines are often specified by dual hairpin guide RNAs, with one or both hairpins identifying a target uridine. In this issue of

Indexed as

PseudouridineRNARNA, Guide, CRISPR-Cas SystemsRNA Processing, Post-TranscriptionalRNA, RibosomalRNA, Small NucleolarPseudouridineRNARNA, Guide, CRISPR-Cas SystemsRNA, RibosomalRNA, Small Nucleolarbox H/ACA RNAsguide RNA acrobaticspseudouridinepseudouridylationRNA-guided RNA modificationRNA–RNA interaction

Identifiers

PMID35022325
PMCPMC8763051

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.