Evidence map›Paper›PMID 35022318›Full record

ArticleJournal of neurology, neurosurgery, and psychiatry2022

Development of novel clinical examination scales for the measurement of disease severity in Creutzfeldt-Jakob disease.

Akin Nihat, Tze How Mok, Hans Odd, Andrew Geoffrey Bourne Thompson, Diana Caine, Kirsty McNiven, Veronica O'Donnell, Selam Tesfamichael, Peter Rudge, John Collinge and 1 more

Open access · hybridAbstract read
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In one paragraph

Article in Journal of neurology, neurosurgery, and psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Prevalence and Treatments of Movement Disorders in Prion Diseases: A Longitudinal Cohort Study.Movement disorders : official journal of the Movement Disorder Society · 2022
    Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Akin NihatUCL Institute of Prion Diseases, MRC Prion Unit at UCL, London, UK.ORCID 0000-0003-2892-1402
Tze How MokUCL Institute of Prion Diseases, MRC Prion Unit at UCL, London, UK.
Hans OddNational Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, National Prion Clinic, London, UK.
Andrew Geoffrey Bourne ThompsonNational Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, National Prion Clinic, London, UK.
Diana CaineNational Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, National Prion Clinic, London, UK.
Kirsty McNivenNational Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, National Prion Clinic, London, UK.ORCID 0000-0002-7525-2478
Veronica O'DonnellNational Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, National Prion Clinic, London, UK.
Selam TesfamichaelNational Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, National Prion Clinic, London, UK.
Peter RudgeUCL Institute of Prion Diseases, MRC Prion Unit at UCL, London, UK.
John CollingeUCL Institute of Prion Diseases, MRC Prion Unit at UCL, London, UK.
Simon MeadUCL Institute of Prion Diseases, MRC Prion Unit at UCL, London, UK s.mead@prion.ucl.ac.uk.ORCID 0000-0002-4326-1468
University College London Hospitals NHS Foundation Trust · GB

Funding

Medical Research Council MC_UU_00024/1Medical Research Council MR/P019862/1
6 · The paper itself

Abstract

objectiveTo use a robust statistical methodology to develop and validate clinical rating scales quantifying longitudinal motor and cognitive dysfunction in sporadic Creutzfeldt-Jakob disease (sCJD) at the bedside.

methodsRasch analysis was used to iteratively construct interval scales measuring composite cognitive and motor dysfunction from pooled bedside neurocognitive examinations collected as part of the prospective National Prion Monitoring Cohort study, October 2008-December 2016.A longitudinal clinical examination dataset constructed from 528 patients with sCJD, comprising 1030 Motor Scale and 757 Cognitive Scale scores over 130 patient-years of study, was used to demonstrate scale utility.

resultsThe Rasch-derived Motor Scale consists of 8 items, including assessments reliant on pyramidal, extrapyramidal and cerebellar systems. The Cognitive Scale comprises 6 items, and includes measures of executive function, language, visual perception and memory. Both scales are unidimensional, perform independently of age or gender and have excellent inter-rater reliability. They can be completed in minutes at the bedside, as part of a normal neurocognitive examination. A composite Examination Scale can be derived by averaging both scores. Several scale uses, in measuring longitudinal change, prognosis and phenotypic heterogeneity are illustrated.

conclusionsThese two novel sCJD Motor and Cognitive Scales and the composite Examination Scale should prove useful to objectively measure phenotypic and clinical change in future clinical trials and for patient stratification. This statistical approach can help to overcome obstacles to assessing clinical change in rapidly progressive, multisystem conditions with limited longitudinal follow-up.

Indexed as

Creutzfeldt-Jakob SyndromeCohort StudiesHumansProspective StudiesReproducibility of ResultsSeverity of Illness Indexcognitiondementiamotor controlprionscales

Identifiers

PMID35022318
PMCPMC8921594
OpenAlexW4220733541

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.