Evidence map›Paper›PMID 35022288›Full record

ArticleSaudi medical journal2022

Childhood nephrolithiasis and nephrocalcinosis caused by metabolic diseases and renal tubulopathy: A retrospective study from 2 tertiary centers.

Jameela A Kari, Mohamed A Shalaby, Faiza A Qari, Amr S Albanna, Khalid A Alhasan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Saudi medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Kidney Stone Prevention.Advances in nutrition (Bethesda, Md.) · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jameela A KariFrom the Department of Pediatrics (Kari, Shalaby), Pediatric Nephrology Center of Excellence; from the Department of Medicine (Qari), King Abdulaziz University, from King Abdullah International Medical Research Center (Albanna), King Saud Bin Abdulaziz University for Health Sciences, Jeddah, and from the Department of Pediatric (Alhasan), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Mohamed A ShalabyFrom the Department of Pediatrics (Kari, Shalaby), Pediatric Nephrology Center of Excellence; from the Department of Medicine (Qari), King Abdulaziz University, from King Abdullah International Medical Research Center (Albanna), King Saud Bin Abdulaziz University for Health Sciences, Jeddah, and from the Department of Pediatric (Alhasan), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Faiza A QariFrom the Department of Pediatrics (Kari, Shalaby), Pediatric Nephrology Center of Excellence; from the Department of Medicine (Qari), King Abdulaziz University, from King Abdullah International Medical Research Center (Albanna), King Saud Bin Abdulaziz University for Health Sciences, Jeddah, and from the Department of Pediatric (Alhasan), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Amr S AlbannaFrom the Department of Pediatrics (Kari, Shalaby), Pediatric Nephrology Center of Excellence; from the Department of Medicine (Qari), King Abdulaziz University, from King Abdullah International Medical Research Center (Albanna), King Saud Bin Abdulaziz University for Health Sciences, Jeddah, and from the Department of Pediatric (Alhasan), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
Khalid A AlhasanFrom the Department of Pediatrics (Kari, Shalaby), Pediatric Nephrology Center of Excellence; from the Department of Medicine (Qari), King Abdulaziz University, from King Abdullah International Medical Research Center (Albanna), King Saud Bin Abdulaziz University for Health Sciences, Jeddah, and from the Department of Pediatric (Alhasan), College of Medicine, King Saud University, Riyadh, Kingdom of Saudi Arabia.
King Saud bin Abdulaziz University for Health Sciences · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo study childhood nephrolithiasis and nephrocalcinosis caused by metabolic disorders, distal renal tubular acidosis (dRTA), and familial hypomagnesemia, hypercalciuria, and nephrocalcinosis (FHHNC).

methodsWe retrospectively evaluated 86 children presented over 10 years (2011-2021), with nephrolithiasis (89%) and nephrocalcinosis (11%) caused by metabolic disorders (62%), FHHNC (21%), and dRTA (17%).

resultsThe mean age at discovery was 72.7 months. The underlying metabolic etiologies included hyperoxaluria (38%), cystinuria (32%), hypercalciuria (24%), and hyperuricosuria (6%). Genetic testing was carried out for 23 patients. Hyperoxaluria was typically treated medically (75%). However, the majority progressed to end-stage kidney disease (ESKD). Most children with cystinuria, hypercalciuria, and hyperuricosuria required medical and surgical intervention. Patients with FHHNC typically presented with nephrocalcinosis. Genetic testing revealed

conclusionChildhood nephrolithiasis is mainly related to metabolic disorders and is associated with poor renal outcomes. Nephrocalcinosis and nephrolithiasis have poor outcomes when associated with FHHNC, while nephrocalcinosis associated with dRTA has relatively good renal outcomes.

Indexed as

NephrocalcinosisNephrolithiasisChildGenetic TestingHumansHypercalciuriaRetrospective Studiesdistal renal tubular acidosisFHHNCnephrolithiasis

Identifiers

PMID35022288
PMCPMC9280569
OpenAlexW4205775222

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.