Evidence map›Paper›PMID 35021482›Full record

ArticleACS applied bio materials2019

MRI-Guided, Noninvasive Delivery of Magneto-Electric Drug Nanocarriers to the Brain in a Nonhuman Primate.

Ajeet Kaushik, Jose Rodriguez, Dan Rothen, Vinay Bhardwaj, Rahul Dev Jayant, Pradip Pattany, Beatriz Fuentes, Hitendra Chand, Nagesh Kolishetti, Nazira El-Hage and 3 more

Open access · greenAbstract read
In one paragraph

Article in ACS applied bio materials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 49 citations in OpenAlex.

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  13. Noninvasive Delivery of Biologicals to the Brain.Focus (American Psychiatric Publishing) · 2022
    Article
  14. Review
  15. Carbon-coated FeNanoscale advances · 2021
    Article
  16. Review
  17. A New Type of MgFeInternational journal of nanomedicine · 2020
    Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Ajeet KaushikCenter of Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.ORCID http://orcid.org/0000-0003-4206-1541
Jose Rodriguez
Dan Rothen
Vinay BhardwajDepartment of Biomedical Engineering, Rutgers University, Piscataway, New Jersey 08901, United States.
Rahul Dev JayantDepartment of Pharmaceutical Sciences, School of Pharmacy, Texas Tech University Health Sciences Center, Amarillo, Texas 79106, United States.
Pradip Pattany
Beatriz Fuentes
Hitendra ChandCenter of Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.ORCID http://orcid.org/0000-0002-0574-9307
Nagesh KolishettiCenter of Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.ORCID http://orcid.org/0000-0001-5574-673X
Nazira El-HageCenter of Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.
Kamel KhaliliDepartment of Neuroscience, Lewis Katz School of Medicine, Temple University, Philadelphia, Pennsylvania 19140, United States.
Norma S KenyonCell Transplant Center, Diabetes Research Institute, Miller School of Medicine University of Miami, Miami, Florida 33136, United States.
Madhavan NairCenter of Personalized Nanomedicine, Institute of Neuroimmune Pharmacology, Department of Immunology and Nano-Medicine, Herbert Wertheim College of Medicine, Florida International University, Miami, Florida 33199, United States.
Florida International University · USUniversity of Miami · USRutgers, The State University of New Jersey · USTemple University · USTexas Tech University · US

Funding

Nanotechnology Based Gene Editing to Eradicate HIV Brain Reservoir in Drug AbusersR01DA042706 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI KHALILI, KAMEL, NAIR, MADHAVAN P. · 2016 to 2020
$3.2M
To evaluate the role of cannabinoid signaling during the comorbidity of HIV and Alzheimer¿s disease in the context of HIV-associated cognitive disordersR01DA040537 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2015 to 2019
$3.0M
Cocaine in the Neuropathogenesis of HIV infection: Role of HDAC2R01DA034547 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2013 to 2018
$1.8M
Multifunctional Nanocarrier to Eradicate HIV from latently infected CNS cells andR01DA037838 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI NAIR, MADHAVAN P. · 2014 to 2018
$1.8M
NIDA NIH HHS R01 DA034547NIDA NIH HHS R01 DA037838NIDA NIH HHS R01 DA040537NIDA NIH HHS R01 DA042706
6 · The paper itself

Abstract

A magnetically guided brain delivery method previously demonstrated in mice has not yet been translated for clinical applications due to the mismatch of available static magnet dimensions in relation to the human brain size and shape. To develop a human-compatible methodology, we explored magnetic resonance imaging (MRI) as a tool for the delivery of magneto-electric nanoparticles (MENPs) into the brain of a baboon, as a proof-of-concept study. MRI brain image analysis showed a reduction in

Indexed as

brain deliverydrug nanocarriersmagnetic resonance imaging (MRI)magneto-electro nanoparticles (MENPs)personalized nanomedicine

Identifiers

PMID35021482
PMCPMC10077812
OpenAlexW2978480808

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.