Evidence map›Paper›PMID 35021099›Full record

ArticleCell reports2022

Stimulation of a subset of natural killer T cells by CD103

Mallory Paynich Murray, Catherine M Crosby, Paola Marcovecchio, Nadine Hartmann, Shilpi Chandra, Meng Zhao, Archana Khurana, Sonja P Zahner, Björn E Clausen, Fadie T Coleman and 3 more

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Review
  3. Leukocyte kinetics and bacterial clearance duringAmerican journal of physiology. Lung cellular and molecular physiology · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Invariant natural killer T cells in lung diseases.Experimental & molecular medicine · 2023
    Review
  8. Review
  9. Article
  10. Frontiers in immunology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 2 countries.

Mallory Paynich MurrayDivision of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Catherine M CrosbyDivision of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Paola MarcovecchioMicroscopy and Histology Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Nadine HartmannDivision of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Shilpi ChandraDivision of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Meng ZhaoDivision of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Archana KhuranaDivision of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Sonja P ZahnerDivision of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Björn E ClausenInstitute for Molecular Medicine, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz 55131, Germany.
Fadie T ColemanPulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA.
Joseph P MizgerdPulmonary Center, Boston University School of Medicine, Boston, MA 02118, USA.
Zbigniew MikulskiMicroscopy and Histology Core Facility, La Jolla Institute for Immunology, La Jolla, CA 92037, USA.
Mitchell KronenbergDivision of Developmental Immunology, La Jolla Institute for Immunology, La Jolla, CA 92037, USA; Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: mitch@lji.org.
La Jolla Institute for Immunology · USBoston University · USJohannes Gutenberg University Mainz · DE

Funding

Pneumonia BiologyR35HL135756 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2017 to 2023
$6.6M
Lung-resident antibacterial heterotypic immunityR01AI115053 · NIAID · BOSTON UNIVERSITY MEDICAL CAMPUS · PI MIZGERD, JOSEPH P · 2015 to 2023
$4.0M
Host nutrients permit immune evasion of NKT cell anti-bacterial responsesR01AI137230 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2018 to 2022
$3.1M
Training in Immunological MechanismsT32AI125179 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2016 to 2025
$3.1M
Differentiation of subsets of NKT cellsR01AI071922 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2016 to 2020
$2.7M
The role of natural killer T cells in the innate response to lung infectionR01AI105215 · NIAID · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI KRONENBERG, MITCHELL · 2014 to 2018
$2.2M
CyTOF Mass CytometerS10OD018499 · OD · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROTTY, SHANE P · 2014 to 2014
$802k
FACSAria II Cell SorterS10RR027366 · NCRR · LA JOLLA INSTITUTE FOR IMMUNOLOGY · PI CROFT, MICHAEL · 2011 to 2011
$514k
NCRR NIH HHS S10 RR027366NHLBI NIH HHS R35 HL135756NIAID NIH HHS R01 AI071922NIAID NIH HHS R01 AI105215NIAID NIH HHS R01 AI115053NIAID NIH HHS R01 AI137230NIAID NIH HHS T32 AI125179NIH HHS S10 OD018499
6 · The paper itself

Abstract

Innate-like T cells, including invariant natural killer T cells, mucosal-associated invariant T cells, and γδ T cells, are present in various barrier tissues, including the lung, where they carry out protective responses during infections. Here, we investigate their roles during pulmonary pneumococcal infection. Following infection, innate-like T cells rapidly increase in lung tissue, in part through recruitment, but T cell antigen receptor activation and cytokine production occur mostly in interleukin-17-producing NKT17 and γδ T cells. NKT17 cells are preferentially located within lung tissue prior to infection, as are CD103

Indexed as

AnimalsCell LineDendritic CellsFemaleGranulocyte-Macrophage Colony-Stimulating FactorHumansInterferon-gammaInterleukin-17Intraepithelial LymphocytesLungLymphocyte ActivationMaleMiceMice, Inbred C57BLNatural Killer T-CellsPneumococcal InfectionsGranulocyte-Macrophage Colony-Stimulating FactorInterferon-gammaInterleukin-17Receptors, Antigen, T-Cell, gamma-deltacytokinedendritic cellinnatelung infectionnatural killer T cellStreptococcus pneumoniaeT cellγδ T cell

Identifiers

PMID35021099
PMCPMC8934033
OpenAlexW4206398574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.