ArticleCell reports2022
Stride-level analysis of mouse open field behavior using deep-learning-based pose estimation.
Article in Cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does advancement in marker-less pose-estimation mean more quality research? A systematic review.Frontiers in behavioral neuroscience · 2025Pooled it
- The choice-wide behavioral association study: data-driven identification of interpretable behavioral components.Nature communications · 2026Article
- Article
- Adoption of MMPose, a general purpose pose estimation library, for animal tracking.bioRxiv : the preprint server for biology · 2026Article
- Optimizing Intermediate Representations: A Framework for Low-Cost, High-Accuracy Behavior Quantification.bioRxiv : the preprint server for biology · 2026Article
- Integrating supervised and unsupervised machine learning for behavior segmentation reveals latent frailty signatures and improves aging clocks in isogenic and outbred mice.bioRxiv : the preprint server for biology · 2026Article
- Article
- Cerebellar tonic inhibition orchestrates the maturation of information processing and motor coordination.Experimental & molecular medicine · 2026Article
- Development of a deep learning-based grid walking test for assessing post-stroke motor function in mice.Frontiers in behavioral neuroscience · 2026Article
- Strain- and age-dependent divergence in mouse appetitive spatial learning and decision strategies.Frontiers in behavioral neuroscience · 2026Article
- AI-driven decoding of naturalistic behaviors enables tailored detection of depressive-like behavior in mice.Nature communications · 2025Article
- Visual detection of seizures in mice using supervised machine learning.Cell reports methods · 2025Article
- Mice carrying the human dopamine D2 receptor pathogenic mutation p.Met374Arg exhibit hyperactivity and aberrant D2 receptor function.Molecular pharmacology · 2025Article
- Integrating artificial intelligence and optogenetics for Parkinson's disease diagnosis and therapeutics in male mice.Nature communications · 2025Article
- Machine vision-based frailty assessment for genetically diverse mice.GeroScience · 2025Article
- A common computational and neural anomaly across mouse models of autism.Nature neuroscience · 2025Article
- Age- and sex-specific deterioration on bone and osteocyte lacuno-canalicular network in a mouse model of premature aging.Bone research · 2025Article
- Anti-drift pose tracker (ADPT), a transformer-based network for robust animal pose estimation cross-species.eLife · 2025Article
- Using Computational Video Analysis in Aging Mice to Evaluate the Effects of Chronic Monotherapy, Polypharmacy, and Deprescribing Over Time.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Gait and posture are often perturbed in many neurological, neuromuscular, and neuropsychiatric conditions. Rodents provide a tractable model for elucidating disease mechanisms and interventions. Here, we develop a neural-network-based assay that adopts the commonly used open field apparatus for mouse gait and posture analysis. We quantitate both with high precision across 62 strains of mice. We characterize four mutants with known gait deficits and demonstrate that multiple autism spectrum disorder (ASD) models show gait and posture deficits, implying this is a general feature of ASD. Mouse gait and posture measures are highly heritable and fall into three distinct classes. We conduct a genome-wide association study to define the genetic architecture of stride-level mouse movement in the open field. We provide a method for gait and posture extraction from the open field and one of the largest laboratory mouse gait and posture data resources for the research community.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.