ArticleImmunity2022
TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures.
Open access · bronzeAbstract read
In one paragraph
Article in Immunity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 2 pooled it
17.1field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
127 citing papers in PubMed, 2 syntheses or guidelines pooled it, 165 citations in OpenAlex.
- Prognostic value of tertiary lymphoid structures (TLS) in digestive system cancers: a systematic review and meta-analysis.BMC cancer · 2023Pooled it
- The soldiers needed to be awakened: Tumor-infiltrating immune cells.Frontiers in genetics · 2022Pooled it
- Efficacy, safety and single-cell analysis of neoadjuvant immunochemotherapy in locally advanced oral squamous cell carcinoma: a phase II trial.Nature communications · 2025Trial
- Neo-adjuvant pembrolizumab in stage IV high-grade serous ovarian cancer: the phase II Neo-Pembro trial.Nature communications · 2025Trial
- Microenvironmental network of clonal CXCL13+CD4+ T cells and Tregs in pemphigus chronic blisters.The Journal of clinical investigation · 2023Trial
- Aging-associated SATB1 deficiency remodels 3D genome architecture and transcriptional programs in naive CD4Science advances · 2026Article
- SATB1 preserves CD4Life science alliance · 2026Article
- Tumor-infiltrating plasma cell profiling after PD-1 blockade reveals tumor-specific antibodies.Cancer cell · 2026Article
- Deep learning CT signature for predicting early liver metastases in pancreatic ductal adenocarcinoma.Nature communications · 2026Observational
- Review
- Isotype-switched antibodies originating from tertiary lymphoid structures can antagonize ovarian cancer progression.iScience · 2026Article
- Clonal sharing and plasticity of follicular CD4 + T cells across lymph nodes and tumors in non-small cell lung cancer.Nature communications · 2026Article
- Migration of immune cells in tumors and inflammation: molecular mechanisms and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Anti-PD-1 plus anti-CTLA-4 blockade overcomes immune exclusion in NSCLC brain metastases by enhancing CD8Nature communications · 2026Article
- Adaptive resistance in cancer immunotherapy.Cellular & molecular immunology · 2026Review
- SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells.EMBO reports · 2026Article
- Tumor infiltrating B cells and tertiary lymphoid structures in pancreatic cancer prognosis and therapy.iScience · 2026Review
- Article
- CNS1-dependent regulatory T cells shape recovery from acute lung injury.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- HIF-1αImmunity · 2026Article
67 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
26 authors at 2 institutions in 1 country.
Ricardo A ChaurioDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Carmen M AnadonDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Tara Lee CostichDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Kyle K PayneDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Subir BiswasDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Carly M HarroDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Carlos MoranDepartments of Pathology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Antonio C OrtizDepartments of Analytic Microscopy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Carla CortinaDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Kristen E RigolizzoDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Kimberly B SprengerDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Jessica A MineDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Patrick InnamaratoDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Gunjan MandalDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
John J PowersDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Alexandra MartinDepartments of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Zhitao WangDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Sumit MehtaDepartments of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Bradford A PerezDepartments of Radiation Therapy, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Roger LiDepartments of Genitourinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
John RobinsonDepartments of Flow Cytometry Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Jodi L KroegerDepartments of Flow Cytometry Core, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Tyler J CurielMays Cancer Center, University of Texas Health, San Antonio, TX 78229, USA.
Xiaoqing YuDepartments of Biostatistics and Bioinformatics, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Paulo C RodriguezDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA.
Jose R Conejo-GarciaDepartments of Immunology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Departments of Gynecologic Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA; Departments of Malignant Hematology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. Electronic address: jose.conejo-garcia@moffitt.org.
Moffitt Cancer Center · USThe University of Texas Health Science Center at San Antonio · US
Funding
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI Christine O'Connell · 1998 to 2026
$93.5MIMMUNOBIOLOGY OF NORMAL AND NEOPLASTIC LYMPHOCYTEST32CA009140 · NCI · UNIVERSITY OF PENNSYLVANIA · PI Malay Haldar, WARREN S PEAR · 1985 to 2026
$16.1MVascular Leukocytes Influence the Tumor MicroenvironmentR01CA124515 · NCI · WISTAR INSTITUTE · PI Jose R Conejo-Garcia · 2007 to 2026
$7.1MRapid Exoproteome Antigen Profiling of antibodies produced in the ovarian cancer microenvironmentU01CA232758 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI CONEJO-GARCIA, JOSE R · 2018 to 2022
$4.1MInitiation and Evolution of the Ovarian Cancer MicroenvironmentR01CA157664 · NCI · WISTAR INSTITUTE · PI CONEJO-GARCIA, JOSE R · 2011 to 2020
$3.8MTargetable epigenetic mechanism driving Cutaneous T cell LymphomaR01CA240434 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI CONEJO-GARCIA, JOSE R, PINILLA, JAVIER · 2019 to 2023
$2.6MPlant-derived extracts regulate immunosuppressive myelopoiesis in Breast cancer patientsR01CA262121 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2021 to 2025
$2.1MFunctional reprogramming of tumor-MDSC through antibody-based therapies targeting Notch ligandsR01CA233512 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI RODRIGUEZ, PAULO CESAR · 2019 to 2023
$2.0MDeveloping a Human in Mouse Cancer Model with a Completely Humanized StromaR01CA211913 · NCI · MAGEE-WOMEN'S RES INST AND FOUNDATION · PI BUCKANOVICH, RONALD J · 2017 to 2020
$1.9MEffects of Common Polymorphisms in Immune Sensors in Tumor ImmunosurveillanceR01CA178687 · NCI · WISTAR INSTITUTE · PI CONEJO-GARCIA, JOSE R · 2013 to 2017
$1.9MStress Pathways in Tumors Drive Global MDSC Activity and Survival through ChopR01CA184185 · NCI · LSU HEALTH SCIENCES CENTER · PI RODRIGUEZ, PAULO CESAR · 2015 to 2019
$1.8MFinding Synergy with Radiation Therapy and Immunotherapy for Patients with Lung CancerK08CA231454 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI PEREZ, BRADFORD A. · 2019 to 2023
$1.2MNCI NIH HHS K08 CA231454NCI NIH HHS P30 CA076292NCI NIH HHS R01 CA124515NCI NIH HHS R01 CA157664NCI NIH HHS R01 CA178687NCI NIH HHS R01 CA184185NCI NIH HHS R01 CA211913NCI NIH HHS R01 CA233512NCI NIH HHS R01 CA240434NCI NIH HHS R01 CA262121NCI NIH HHS T32 CA009140NCI NIH HHS U01 CA232758
Abstract
The immune checkpoint receptor PD-1 on T follicular helper (Tfh) cells promotes Tfh:B cell interactions and appropriate positioning within tissues. Here, we examined the impact of regulation of PD-1 expression by the genomic organizer SATB1 on Tfh cell differentiation. Vaccination of CD4
Indexed as
AnimalsCell DifferentiationGene Expression RegulationGene SilencingGenotypeGerminal CenterLymphocytes, Tumor-InfiltratingMatrix Attachment Region Binding ProteinsMiceMice, Inbred C57BLMice, KnockoutProgrammed Cell Death 1 ReceptorTertiary Lymphoid StructuresT-Lymphocytes, Helper-InducerTransforming Growth Factor betaMatrix Attachment Region Binding ProteinsPdcd1 protein, mouseProgrammed Cell Death 1 ReceptorSatb1 protein, mouseTransforming Growth Factor betaB cell cancerimmuno-oncologySATB1tertiary lymphoid structureT follicular helper celltumor immunology
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.