Evidence map›Paper›PMID 35020973›Full record

ArticleInsect science2022

Ecdysis triggering hormone peptide in the African malaria mosquito Anopheles gambiae: The peptide structure for receptor activation.

Hawa Dembele, Moritz Mating, Rupinder Singh, Soheila Fatehi, Alvaro I Herrera, Yoonseong Park, Om Prakash

Open access · hybridAbstract read
In one paragraph

Article in Insect science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. New Insights into theJournal of agricultural and food chemistry · 2023
    Review
  2. The Active Site of the Enzyme 10-Formyl-THFDH in the Honey BeeInternational journal of molecular sciences · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Hawa DembeleDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, 66506.
Moritz MatingDepartment of Entomology, Kansas State University, Manhattan, Kansas, 66506.
Rupinder SinghDepartment of Entomology, Kansas State University, Manhattan, Kansas, 66506.
Soheila FatehiDepartment of Entomology, Kansas State University, Manhattan, Kansas, 66506.
Alvaro I HerreraDepartment of Chemistry & Biochemistry, Auburn University, Auburn, Alabama, USA.
Yoonseong ParkDepartment of Entomology, Kansas State University, Manhattan, Kansas, 66506.ORCID https://orcid.org/0000-0003-1191-7335
Om PrakashDepartment of Biochemistry and Molecular Biophysics, Kansas State University, Manhattan, Kansas, 66506.
Kansas State University · USAuburn University · US

Funding

Mentoring CoreP20GM103418 · NIGMS · UNIVERSITY OF KANSAS MEDICAL CENTER · PI SUSAN J. BROWN · 2012 to 2026
$63.0M
Console Upgrade and Cryogenic Probe for a 500 MHz NMR System for Biomedical ResearchS10OD026726 · OD · KANSAS STATE UNIVERSITY · PI PRAKASH, OM · 2019 to 2019
$600k
Discovery of GPCR-targeted insecticides for malaria mosquito controlR21AI135457 · NIAID · KANSAS STATE UNIVERSITY · PI PARK, YOONSEONG · 2018 to 2019
$430k
Development of osmoregulation disruptors for tick controlR21AI163423 · NIAID · KANSAS STATE UNIVERSITY · PI PARK, YOONSEONG · 2021 to 2022
$418k
National Institute of Allergy and Infectious Diseases 1S10OD026726National Institute of Allergy and Infectious Diseases AI135457National Institute of Allergy and Infectious Diseases AI163423National Institute of Food and Agriculture GRANT13066347NIAID NIH HHS R21 AI135457NIAID NIH HHS R21 AI163423NIGMS NIH HHS P20 GM103418(NIH) P20GM103418NIH HHS S10 OD026726
6 · The paper itself

Abstract

Infections by mosquito-borne diseases represent one of the leading causes of death in third world countries. The rapid progression of resistance to conventional insecticide causes a significant threat to the highly efficient preventive methods currently in place. Insect neuropeptidergic system offers potential targets to control the insect vectors. The essential roles of the neuropeptide ecdysis triggering hormone (ETH) in insect development and reproduction led us to attempt understanding of the fundamentals of the biochemical interaction between ETH and its receptor in the African malaria mosquito Anopheles gambiae. One of two ETH peptides of the African malaria mosquito (AgETH1), a small peptide hormone with 17 amino acid residues (SESPGFFIKLSKSVPRI-NH

Indexed as

AnophelesInsecticidesMalariaNeuropeptidesPeptide HormonesAmino AcidsAnimalsHormonesInsectaInsecticide ResistanceLigandsMoltingMosquito ControlMosquito VectorsAmino AcidsHormonesInsecticidesLigandsNeuropeptidesPeptide HormonesAnopheles gambiaeecdysis triggering hormoneG protein-coupled receptorinsectmalarianeuropeptideNMR spectroscopy

Identifiers

PMID35020973
PMCPMC9273798
OpenAlexW4205122773

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.