Evidence map›Paper›PMID 35020838›Full record

ArticleClinical and experimental immunology2022

Diagnosis of HLH: two siblings, two distinct genetic causes.

Claire Escaron, Elizabeth Ralph, Shahnaz Bibi, Johannes Visser, Maurizio Aricò, Kanchan Rao, Paul Veys, Kimberly Gilmour

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and experimental immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Claire EscaronImmunology Laboratory, Great Ormond Street Hospital, London, UK.
Elizabeth RalphImmunology Laboratory, Great Ormond Street Hospital, London, UK.
Shahnaz BibiGenetics Laboratory, Great Ormond Street Hospital, London, UK.
Johannes VisserDepartment of Paediatric Oncology, Addenbrookes Hospital, Cambridge University Hospitals, Cambridge, UK.
Maurizio AricòAzienda Ospedaliero-Universitaria Consorziale Policlinico Bari, Children Hospital 13 Giovanni XXIII, Bari, Italy.
Kanchan RaoDepartment of Bone Marrow Transplant, Great Ormond Street Hospital for Children, London, UK.
Paul VeysDepartment of Bone Marrow Transplant, Great Ormond Street Hospital for Children, London, UK.
Kimberly GilmourImmunology Laboratory, Great Ormond Street Hospital, London, UK.

Funding

Department of Health
6 · The paper itself

Abstract

This report highlights case of two siblings who developed haemophagocytic lymphohystiocytosis due to distinct genetic abnormalities. Though their presentation was clinically similar, the cases demonstrate that a shared genetic diagnosis among siblings cannot be assumed.

Indexed as

Lymphohistiocytosis, HemophagocyticHumansSiblingsgenetic pedigreehaemophagocytic lymphohystiocytosismolecular diagnosticsprimary immunodeficiencyX-linked lymphoproliferative syndrome

Identifiers

PMID35020838
PMCPMC8982960

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.