Evidence map›Paper›PMID 35020725›Full record

SynthesisPloS one

People who inject drugs in metropolitan Chicago: A meta-analysis of data from 1997-2017 to inform interventions and computational modeling toward hepatitis C microelimination.

Basmattee Boodram, Mary Ellen Mackesy-Amiti, Aditya Khanna, Bryan Brickman, Harel Dahari, Jonathan Ozik

Abstract readMeta-Analysis
In one paragraph

Synthesis in PloS one. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Basmattee BoodramDivision of Community Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, United States of America.
Mary Ellen Mackesy-AmitiDivision of Community Health Sciences, School of Public Health, University of Illinois at Chicago, Chicago, Illinois, United States of America.ORCID https://orcid.org/0000-0002-7238-5240
Aditya KhannaDepartment of Behavioral and Social Sciences, School of Public Health, Brown University, Providence, Rhode Island, United States of America.ORCID https://orcid.org/0000-0003-1049-3374
Bryan BrickmanDepartment of Medicine, Chicago Center for HIV Elimination, University of Chicago, Chicago, Illinois, United States of America.ORCID https://orcid.org/0000-0003-0313-8227
Harel DahariDivision of Hepatology, Department of Medicine, Loyola University Medical Center, Maywood, Illinois, United States of America.
Jonathan OzikDecision and Infrastructure Sciences Division, Argonne National Laboratory, Lemont, Illinois, United States of America.ORCID https://orcid.org/0000-0002-3495-6735

Funding

Computational modeling for HCV vaccine trial design and optimal vaccine-based combination interventionsR01AI158666 · NIAID · LOYOLA UNIVERSITY CHICAGO · PI Basmattee Boodram, Harel Dahari · 2022 to 2026
$3.5M
Contextual risk factors for hepatitis C among young persons who inject drugsR01DA043484 · NIDA · UNIVERSITY OF ILLINOIS AT CHICAGO · PI BOODRAM, BASMATTEE · 2017 to 2021
$2.9M
Computational discovery of effective hepatitis C intervention strategiesR01GM121600 · NIGMS · LOYOLA UNIVERSITY CHICAGO · PI BOODRAM, BASMATTEE, DAHARI, HAREL · 2017 to 2021
$2.0M
NIAID NIH HHS R01 AI158666NIDA NIH HHS R01 DA043484NIGMS NIH HHS R01 GM121600
6 · The paper itself

Abstract

Progress toward hepatitis C virus (HCV) elimination in the United States is not on track to meet targets set by the World Health Organization, as the opioid crisis continues to drive both injection drug use and increasing HCV incidence. A pragmatic approach to achieving this is using a microelimination approach of focusing on high-risk populations such as people who inject drugs (PWID). Computational models are useful in understanding the complex interplay of individual, social, and structural level factors that might alter HCV incidence, prevalence, transmission, and treatment uptake to achieve HCV microelimination. However, these models need to be informed with realistic sociodemographic, risk behavior and network estimates on PWID. We conducted a meta-analysis of research studies spanning 20 years of research and interventions with PWID in metropolitan Chicago to produce parameters for a synthetic population for realistic computational models (e.g., agent-based models). We then fit an exponential random graph model (ERGM) using the network estimates from the meta-analysis in order to develop the network component of the synthetic population.

Indexed as

Computer SimulationAdolescentAdultChicagoDrug UsersFemaleHepatitis CHumansIncidenceMaleMiddle AgedRisk-TakingSocial ClassYoung Adult

Identifiers

PMID35020725
PMCPMC8754317

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.