Evidence map›Paper›PMID 35020600›Full record

ArticleAging2022

PEGylation and antioxidant effects of a human glutathione peroxidase 1 mutant.

Guang-Yuan Zhang, Yan-Wei Wang, Li-Ying Guo, Liang-Ru Lin, Shao-Peng Niu, Chang-Hao Xiong, Jing-Yan Wei

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Guang-Yuan ZhangCollege of Pharmaceutical Science, Jilin University, Changchun 130021, PR China.
Yan-Wei WangCollege of Pharmaceutical Science, Jilin University, Changchun 130021, PR China.
Li-Ying GuoCollege of Pharmaceutical Science, Jilin University, Changchun 130021, PR China.
Liang-Ru LinCollege of Pharmaceutical Science, Jilin University, Changchun 130021, PR China.
Shao-Peng NiuCollege of Pharmaceutical Science, Jilin University, Changchun 130021, PR China.
Chang-Hao XiongCollege of Pharmaceutical Science, Jilin University, Changchun 130021, PR China.
Jing-Yan WeiCollege of Pharmaceutical Science, Jilin University, Changchun 130021, PR China.
Jilin University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Human glutathione peroxidase1 (hGPx1) is a good antioxidant and potential drug, but the limited availability and poor stability of hGPx1 have affected its development and application. To solve this problem, we prepared a hGPx1 mutant (GPx1M) with high activity in an

Indexed as

AnimalsAntioxidantsCell LineDrug DesignEscherichia coliGlutathione PeroxidaseGlutathione Peroxidase GPX1HumansHydrogen-Ion ConcentrationModels, MolecularMutationMyocytes, CardiacPolyethylene GlycolsProtein ConformationProtein StabilityRatsAntioxidantsGlutathione PeroxidaseGlutathione Peroxidase GPX1methoxypolyethylene glycol succinimidylsuccinatePolyethylene GlycolsSuccinimidesantioxidantcardiotoxicityhuman glutathione peroxidase 1 mutantPEGylationthermal stability

Identifiers

PMID35020600
PMCPMC8791217
OpenAlexW4206398958

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.