Evidence map›Paper›PMID 35020516›Full record

ArticleJournal of neurophysiology2022

A topographical and physiological exploration of C-tactile afferents and their response to menthol and histamine.

Line S Löken, Helena Backlund Wasling, Håkan Olausson, Francis McGlone, Johan Wessberg

Abstract read
In one paragraph

Article in Journal of neurophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Functional and molecular diversity of human C-fibers in pain modulation.Current opinion in supportive and palliative care · 2026
    Review
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  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Line S LökenDepartment of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.ORCID 0000-0001-6762-9717
Helena Backlund WaslingDepartment of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.
Håkan OlaussonDepartment of Biomedical and Clinical Sciences, Center for Social and Affective Neuroscience, Linköping University, Linköping, Sweden.
Francis McGloneResearch Centre for Brain & Behaviour, School of Natural Sciences and Psychology, Liverpool John Moores University, Liverpool, United Kingdom.ORCID 0000-0002-0881-635X
Johan WessbergDepartment of Physiology, Institute of Neuroscience and Physiology, University of Gothenburg, Gothenburg, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Unmyelinated tactile (C-tactile or CT) afferents are abundant in arm hairy skin and have been suggested to signal features of social affective touch. Here, we recorded from unmyelinated low-threshold mechanosensitive afferents in the peroneal and radial nerves. The most distal receptive fields were located on the proximal phalanx of the third finger for the superficial branch of the radial nerve and near the lateral malleolus for the peroneal nerve. We found that the physiological properties with regard to conduction velocity and mechanical threshold, as well as their tuning to brush velocity, were similar in CT units across the antebrachial (

Indexed as

AffectAdultAfferent PathwaysAntipruriticsFemaleHistamineHistamine AgonistsHumansLegMaleMechanoreceptorsMentholNerve Fibers, UnmyelinatedNociceptorsPeroneal NerveRadial NerveAntipruriticsHistamineHistamine AgonistsMentholaffective touchCT afferenthistaminementholperoneal nerve

Identifiers

PMID35020516
PMCPMC9190740

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.