Evidence map›Paper›PMID 35020456›Full record

ArticleApplied and environmental microbiology2022

High-Level Production of Isoleucine and Fusel Alcohol by Expression of the Feedback Inhibition-Insensitive Threonine Deaminase in

Shota Isogai, Akira Nishimura, Atsushi Kotaka, Naoyuki Murakami, Natsuki Hotta, Hiroki Ishida, Hiroshi Takagi

Open access · hybridAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. The impact ofFood chemistry: X · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shota IsogaiDivision of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technologygrid.260493.a, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
Akira NishimuraDivision of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technologygrid.260493.a, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
Atsushi KotakaResearch Institute, Gekkeikan Sake Co. Ltd., 101 Shimotoba-koyanagi-cho, Fushimi-ku, Kyoto 612-8385, Japan.
Naoyuki MurakamiResearch Institute, Gekkeikan Sake Co. Ltd., 101 Shimotoba-koyanagi-cho, Fushimi-ku, Kyoto 612-8385, Japan.
Natsuki HottaResearch Institute, Gekkeikan Sake Co. Ltd., 101 Shimotoba-koyanagi-cho, Fushimi-ku, Kyoto 612-8385, Japan.
Hiroki IshidaResearch Institute, Gekkeikan Sake Co. Ltd., 101 Shimotoba-koyanagi-cho, Fushimi-ku, Kyoto 612-8385, Japan.
Hiroshi TakagiDivision of Biological Science, Graduate School of Science and Technology, Nara Institute of Science and Technologygrid.260493.a, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.ORCID 0000-0002-1786-3174
KAN Research Institute · JPNara Institute of Science and Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A variety of the yeast Saccharomyces cerevisiae with intracellular accumulation of isoleucine (Ile) would be a promising strain for developing a distinct kind of sake, a traditional Japanese alcoholic beverage, because Ile-derived volatile compounds have a great impact on the flavor and taste of fermented foods. In this study, we isolated an Ile-accumulating mutant (strain K9-I48) derived from a diploid sake yeast of S. cerevisiae by conventional mutagenesis. Strain K9-I48 carries a novel mutation in the

Indexed as

Saccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsAlcoholic BeveragesEthanolFeedbackFermentationIsoleucineThreonine DehydrataseEthanolIsoleucineSaccharomyces cerevisiae ProteinsThreonine Dehydrataseallosteric regulationfusel alcoholisoleucineSaccharomyces cerevisiaesake yeastthreonine deaminase Ilv1

Identifiers

PMID35020456
PMCPMC8904041
OpenAlexW4206628974

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.