ArticleScience advances2022
Tumor collection/processing under physioxia uncovers highly relevant signaling networks and drug sensitivity.
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Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
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Who cites it
30 citing papers in PubMed.
- Dual-oxygen pancreatic cancer organoids recapitulate basal-classical heterogeneity validated by spatial transcriptomics.British journal of cancer · 2026Article
- Physioxia Reprograms Glioblastoma Cells Enhancing Migration and Altering Therapeutic Sensitivity.Cancers · 2026Article
- C-X-C chemokine receptor type 4 (CXCR4) antagonism in precision oncology: Clinical applications and future directions.Cancer pathogenesis and therapy · 2026Review
- MicroRNA-153-3p targets repressor element 1-silencing transcription factor (REST) and neuronal differentiation: Implications for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- METTL14-mediated miR-122-5p maturation stimulated tumor progression by targeting KAT2A in hepatocellular carcinoma.Scientific reports · 2025Article
- EMC3 is critical for CFTR function and calcium mobilization in the mouse intestinal epithelium.American journal of physiology. Gastrointestinal and liver physiology · 2025Article
- A FRET-based off-on AIE nanoprobe enables instant and stain-free detection of hypoxic niches in tumor sections.Theranostics · 2025Article
- Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions.Science advances · 2024Article
- Oxygen tension-dependent variability in the cancer cell kinome impacts signaling pathways and response to targeted therapies.iScience · 2024Article
- Exosomal HSPB1, interacting with FUS protein, suppresses hypoxia-induced ferroptosis in pancreatic cancer by stabilizing Nrf2 mRNA and repressing P450.Journal of cellular and molecular medicine · 2024Article
- New Ref-1/APE1 targeted inhibitors demonstrating improved potency for clinical applications in multiple cancer types.Pharmacological research · 2024Article
- Article
- A human skeletal muscle stem/myotube model reveals multiple signaling targets of cancer secretome in skeletal muscle.iScience · 2023Article
- Self-adaptive nanoassembly enabling turn-on hypoxia illumination and periphery/center closed-loop tumor eradication.Cell reports. Medicine · 2023Article
- Control of Redox Homeostasis by Short-Chain Fatty Acids: Implications for the Prevention and Treatment of Breast Cancer.Pathogens (Basel, Switzerland) · 2023Review
- Reactive Oxygen Species and NRF2 Signaling, Friends or Foes in Cancer?Biomolecules · 2023Review
- Physiological hypoxia improves growth and functional differentiation of human intestinal epithelial organoids.Frontiers in immunology · 2023Article
- Experimental assessment of robust reference genes for qRT-PCR in lung cancer studies.Frontiers in oncology · 2023Article
- Understanding human aging and the fundamental cell signaling link in age-related diseases: the middle-aging hypovascularity hypoxia hypothesis.Frontiers in aging · 2023Article
- Characterization of endoplasmic reticulum-associated degradation in the human fungal pathogenPeerJ · 2023Article
Corrections and comments
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Authors and funding
20 authors.
Brijesh KumarDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-4725-947X
Adedeji K AdebayoDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-5019-1253
Mayuri PrasadDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Maegan L CapitanoDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Ruizhong WangDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-1190-7594
Poornima Bhat-NakshatriDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-6539-8537
Manjushree AnjanappaDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Edward SimpsonCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-9015-9864
Duojiao ChenCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Yunlong LiuCenter for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-2699-626X
Jeanne M SchilderDepartment of Gynecology and Obstetrics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Austyn B ColterDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-9601-8293
Callista MaguireDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-8878-7327
Constance J TemmDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0002-6619-021X
George SanduskyDepartment of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-0769-057X
Emma H DoudDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0003-0049-0073
Aruna B WijeratneDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-8366-2074
Amber L MosleyDepartment of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-5822-2894
Hal E BroxmeyerDepartment of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-6575-0476
Harikrishna NakshatriDepartment of Surgery, Indiana University School of Medicine, Indianapolis, IN 46202, USA.ORCID 0000-0001-8876-0052
Funding
Tumor Microenvironment and Metastasis ProgramP30CA082709 · NCI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI David W Clapp · 1999 to 2026
$59.3MQuality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2MControlling Influences of Oxygen Tension and CD26/DPP4 Enzymatic Activity on Regulation of Hematopoietic Stem/Progenitor Cells and Hematopoiesis During Health, Ageing, and DiseaseR35HL139599 · NHLBI · INDIANA UNIVERSITY INDIANAPOLIS · PI BROXMEYER, HAL E. · 2018 to 2021
$3.1MNCATS NIH HHS UL1 TR002529NCI NIH HHS P30 CA082709NHLBI NIH HHS R35 HL139599
Abstract
Preclinical studies of primary cancer cells are typically done after tumors are removed from patients or animals at ambient atmospheric oxygen (O
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.