Evidence map›Paper›PMID 35020370›Full record

ArticleACS nano2022

miRNA-Guided Imaging and Photodynamic Therapy Treatment of Cancer Cells Using Zn(II)-Protoporphyrin IX-Loaded Metal-Organic Framework Nanoparticles.

Pu Zhang, Yu Ouyang, Yang Sung Sohn, Michael Fadeev, Ola Karmi, Rachel Nechushtai, Ilan Stein, Eli Pikarsky, Itamar Willner

Open access · hybridAbstract read
In one paragraph

Article in ACS nano, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 81 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Metal-Ligand Complexes as Multifunctional Platforms for Photo-Activated Cancer Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  7. Review
  8. Review
  9. Review
  10. Biodegradable ICG-Conjugated Germanium Nanoparticles forACS applied materials & interfaces · 2024
    Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Review
  16. PhotocleavableChemical reviews · 2023
    Review
  17. Review
  18. Review
  19. Review
  20. Aptamer-Functionalized CeACS applied materials & interfaces · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Pu ZhangInstitute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Yu OuyangInstitute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Yang Sung SohnInstitute of Life Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Michael FadeevInstitute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Ola KarmiInstitute of Life Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Rachel NechushtaiInstitute of Life Science, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.
Ilan SteinThe Lautenberg Center for Immunology and Cancer Research, IMRIC, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Eli PikarskyThe Lautenberg Center for Immunology and Cancer Research, IMRIC, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Itamar WillnerInstitute of Chemistry, Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.ORCID 0000-0001-9710-9077
Hebrew University of Jerusalem · IL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

An analytical platform for the selective miRNA-21-guided imaging of breast cancer cells and miRNA-221-guided imaging of ovarian cancer cells and the selective photodynamic therapy (PDT) of these cancer cells is introduced. The method is based on Zn(II)-protoporphyrin IX, Zn(II)-PPIX-loaded UiO-66 metal-organic framework nanoparticles, NMOFs, gated by two hairpins H

Indexed as

Metal-Organic FrameworksMicroRNAsNanoparticlesNeoplasmsPhotochemotherapyCell Line, TumorPhotosensitizing AgentsPhthalic AcidsProtoporphyrinsZincMetal-Organic FrameworksMicroRNAsPhotosensitizing AgentsPhthalic Acidsprotoporphyrin IXProtoporphyrinsUiO-66Zincbreast cancerfluorescenceG-quadruplexeshybridization chain reactionovarian cancerreactive oxygen species

Identifiers

PMID35020370
PMCPMC8867907
OpenAlexW4205416501

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.