Evidence map›Paper›PMID 35020351›Full record

ArticleACS chemical neuroscience2022

Development of

Sangram Nag, Patricia Miranda-Azpiazu, Zhisheng Jia, Prodip Datta, Ryosuke Arakawa, Mohammad Mahdi Moein, Zhou Yang, Yaoquan Tu, Laetitia Lemoine, Hans Ågren and 3 more

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in ACS chemical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Production of [Molecules (Basel, Switzerland) · 2022
    Article
  8. Diagnostic and Therapeutic Radiopharmaceuticals.ACS pharmacology & translational science · 2022
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Sangram NagDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 76 Stockholm, Sweden.ORCID 0000-0003-3590-4256
Patricia Miranda-AzpiazuDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 76 Stockholm, Sweden.
Zhisheng JiaDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 76 Stockholm, Sweden.
Prodip DattaDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 76 Stockholm, Sweden.
Ryosuke ArakawaDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 76 Stockholm, Sweden.
Mohammad Mahdi MoeinDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 76 Stockholm, Sweden.
Zhou YangDepartment of Physics and Astronomy, Uppsala University, 751 20 Uppsala, Sweden.
Yaoquan TuDivision of Theoretical Chemistry and Biology, Royal Institute of Technology (KTH), 11428 Stockholm, Sweden.ORCID 0000-0001-8198-9284
Laetitia LemoineDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 52 Stockholm Sweden.
Hans ÅgrenDepartment of Physics and Astronomy, Uppsala University, 751 20 Uppsala, Sweden.ORCID 0000-0002-1763-9383
Agneta NordbergDepartment of Neurobiology, Care Sciences and Society, Karolinska Institutet, 141 52 Stockholm Sweden.
Bengt LångströmDepartment of Chemistry, Uppsala University, 75123 Uppsala, Sweden.
Christer HalldinDepartment of Clinical Neuroscience, Centre for Psychiatry Research, Karolinska Institutet and Stockholm County Council, 171 76 Stockholm, Sweden.
Stockholm County Council · SEUppsala University · SEKarolinska Institutet · SEKarolinska University Hospital · SEKTH Royal Institute of Technology · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The homo-pentameric alpha 7 receptor is one of the major types of neuronal nicotinic acetylcholine receptors (α7-nAChRs) related to cognition, memory formation, and attention processing. The mapping of α7-nAChRs by PET pulls a lot of attention to realize the mechanism and development of CNS diseases such as AD, PD, and schizophrenia. Several PET radioligands have been explored for the detection of the α7-nAChR.

Indexed as

Cyclic S-OxidesReceptors, Nicotinicalpha7 Nicotinic Acetylcholine ReceptorAnimalsAzabicyclo CompoundsMolecular Docking SimulationPositron-Emission Tomographyalpha7 Nicotinic Acetylcholine ReceptorAzabicyclo CompoundsCyclic S-OxidesReceptors, Nicotinicautoradiographyin vitroin vivonon-human primatePETradiometabolitesα7-nAChR

Identifiers

PMID35020351
PMCPMC8815074
OpenAlexW4206399390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.