Evidence map›Paper›PMID 35020138›Full record

ArticleMolecular imaging and biology2022

Translational PET Imaging of Spinal Cord Injury with the Serotonin Transporter Tracer [

Hanyi Fang, Samantha Rossano, Xingxing Wang, Nabeel Nabulsi, Brian Kelley, Krista Fowles, Jim Ropchan, Stephen M Strittmatter, Richard E Carson, Yiyun Huang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
  2. Imaging Demyelinated Axons After Spinal Cord Injuries with PET Tracer [Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Hanyi FangPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. fanghanyi@hust.edu.cn.ORCID 0000-0001-8047-4473
Samantha RossanoPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Xingxing WangCellular Neuroscience, Neurodegeneration, and Repair Program, and Departments of Neurology and Neurobiology, Yale School of Medicine, New Haven, CT, USA.
Nabeel NabulsiPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Brian KelleyDepartment of Neurosurgery, University of Pennsylvania, Philadelphia, PA, USA.
Krista FowlesPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Jim RopchanPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Stephen M StrittmatterCellular Neuroscience, Neurodegeneration, and Repair Program, and Departments of Neurology and Neurobiology, Yale School of Medicine, New Haven, CT, USA.
Richard E CarsonPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA.
Yiyun HuangPET Center, Department of Radiology and Biomedical Imaging, Yale School of Medicine, New Haven, CT, USA. henry.huang@yale.edu.
Yale University · USUniversity of Pennsylvania · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Genome-Wide Discovery and Translational Research for Neural RepairR35NS097283 · NINDS · YALE UNIVERSITY · PI STRITTMATTER, STEPHEN M · 2017 to 2024
$8.1M
NCATS NIH HHS UL1 TR001863NINDS NIH HHS R35 NS097283
6 · The paper itself

Abstract

purposeThe descending raphespinal serotonin (5-HT) system contributes to neural activities required for locomotion. The presynaptic serotonin transporter (SERT) is a marker of 5-HT innervation. In this study, we explored the use of PET imaging with the SERT radioligand [ PROCEDURES: PET imaging with [

resultsIntense uptake in the brain and intact spinal cord was observed at 30-60 min post-injection of [

conclusion[

Indexed as

Serotonin Plasma Membrane Transport ProteinsSpinal Cord InjuriesAnimalsCitalopramHumansIndicators and ReagentsPositron-Emission TomographyRatsSerotoninSpinal CordTissue DistributionCitalopramIndicators and ReagentsSerotoninSerotonin Plasma Membrane Transport Proteins[11C]AFMPET imagingSerotonin transporterSpinal cord injury

Identifiers

PMID35020138
PMCPMC9550197
OpenAlexW4206775156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.