Evidence map›Paper›PMID 35020109›Full record

ReviewJournal of neuro-oncology2022

Radiomics for precision medicine in glioblastoma.

Kiran Aftab, Faiqa Binte Aamir, Saad Mallick, Fatima Mubarak, Whitney B Pope, Tom Mikkelsen, Jack P Rock, Syed Ather Enam

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
6.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 51 citations in OpenAlex.

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  18. Artificial intelligence-based MRI radiomics and radiogenomics in glioma.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Kiran AftabSection of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan.
Faiqa Binte AamirMedical College, Aga Khan University, Karachi, Pakistan.
Saad MallickMedical College, Aga Khan University, Karachi, Pakistan.
Fatima MubarakDepartment of Radiology, Aga Khan University, Karachi, Pakistan.
Whitney B PopeDepartment of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Tom MikkelsenDepartments of Neurology and Neurosurgery, Henry Ford Hospital, Detroit, MI, USA.
Jack P RockDepartment of Neurosurgery, Henry Ford Health System, Detroit, MI, USA.
Syed Ather EnamSection of Neurosurgery, Department of Surgery, Aga Khan University, Karachi, Pakistan. ather.enam@aku.edu.ORCID http://orcid.org/0000-0003-2194-0723
Aga Khan University · PKHenry Ford Health System · USHenry Ford Hospital · USUniversity of California, Los Angeles · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionBeing the most common primary brain tumor, glioblastoma presents as an extremely challenging malignancy to treat with dismal outcomes despite treatment. Varying molecular epidemiology of glioblastoma between patients and intra-tumoral heterogeneity explains the failure of current one-size-fits-all treatment modalities. Radiomics uses machine learning to identify salient features of the tumor on brain imaging and promises patient-specific management in glioblastoma patients.

methodsWe performed a comprehensive review of the available literature on studies investigating the role of radiomics and radiogenomics models for the diagnosis, stratification, prognostication as well as treatment planning and monitoring of glioblastoma.

resultsClassifiers based on a combination of various MRI sequences, genetic information and clinical data can predict non-invasive tumor diagnosis, overall survival and treatment response with reasonable accuracy. However, the use of radiomics for glioblastoma treatment remains in infancy as larger sample sizes, standardized image acquisition and data extraction techniques are needed to develop machine learning models that can be translated effectively into clinical practice.

conclusionRadiomics has the potential to transform the scope of glioblastoma management through personalized medicine.

Indexed as

Brain NeoplasmsGlioblastomaHumansMachine LearningMagnetic Resonance ImagingPrecision MedicineGlioblastomaNeuro-oncologyPrimary brain tumorRadiogenomicsRadiomics

Identifiers

PMID35020109
OpenAlexW4206275295

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.