SynthesisHernia : the journal of hernias and abdominal wall surgery2022
Are polypropylene mesh implants associated with systemic autoimmune inflammatory syndromes? A systematic review.
Synthesis in Hernia : the journal of hernias and abdominal wall surgery, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06363903 (Autoimmume/Inflammatory Syndrome Induced by Adjuvants), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Autoimmume/Inflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) Caused by Polypropylene Mesh Implantation - a Pilot Study for Diagnostics and Treatment
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Autoimmunity and hernia mesh: fact or fiction?Hernia : the journal of hernias and abdominal wall surgery · 2023Pooled it
- The developing field of meshology - what is new in the management of mesh complications in female incontinence and prolapse - a systematic review of outcomes.International journal of impotence research · 2026Review
- Polypropylene mesh degradation and systemic disease: biological plausibility is not clinical evidence.Nature reviews. Urology · 2026Article
- What a mesh: a call for better science and regulatory oversight.The British journal of surgery · 2026Article
- Incidence of autoimmune disease after hernia surgery with a mesh implant: national retrospective cohort study.The British journal of surgery · 2026Article
- Patient-Reported Long-Term Outcomes of Laparoscopic Sacrocolpopexy.International urogynecology journal · 2026Article
- Autoimmune syndrome induced by adjuvants (ASIA) following urethral sling placement: A case report.Case reports in women's health · 2026Article
- Response to Commentary: Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) After Polypropylene Mesh Implantation - Protocol of a Pilot Study for Diagnostics and Treatment.Journal of abdominal wall surgery : JAWS · 2025Article
- Autoimmune/Autoinflammatory Syndrome Induced by Adjuvants (ASIA Syndrome) After Polypropylene Mesh Implantation - Protocol of a Pilot Study for Diagnostics and Treatment.Journal of abdominal wall surgery : JAWS · 2025Article
- Complications of Pelvic Prolapse Surgery Using Mesh: A Systematic Review.Journal of personalized medicine · 2024Review
- Prediction of successful revision surgery for mesh-related complaints after inguinal hernia and pelvic organ prolapse repair.Hernia : the journal of hernias and abdominal wall surgery · 2024Article
- The Implant-Induced Foreign Body Response Is Limited by CD13-Dependent Regulation of Ubiquitination of Fusogenic Proteins.Journal of immunology (Baltimore, Md. : 1950) · 2024Article
- Are Surgeons Going to Be Left Holding the Bag? Incisional Hernia Repair and Intra-Peritoneal Non-Absorbable Mesh Implant Complications.Journal of clinical medicine · 2024Review
- Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe surgical implantation of polypropylene (PP) meshes has been linked to the occurrence of systemic autoimmune disorders. We performed a systematic review to determine whether PP implants for inguinal, ventral hernia or pelvic floor surgery are associated with the development of systemic autoimmune syndromes.
methodsWe searched Embase, Medline, Web of Science, Scopus, Cochrane library, clinicaltrialsregister.eu, clinicaltrails.gov and WHO-ICTR platform. Last search was performed on November 24th 2021. All types of studies reporting systemic inflammatory/autoimmune response in patients having a PP implant for either pelvic floor surgery, ventral or inguinal hernia repair were included. Animal studies, case reports and articles without full text were excluded. We intended to perform a meta-analysis. The quality of evidence was assessed with the Newcastle-Ottawa Scale. This study was registered at Prospero (CRD42020220705).
resultsOf 2137 records identified, 4 were eligible. Two retrospective matched cohort studies focused on mesh surgery for vaginal prolapse or inguinal hernia compared to hysterectomy and colonoscopy, respectively. One cohort study compared the incidence of systemic conditions in women having urinary incontinence surgery with and without mesh. These reports had a low risk of bias. A meta-analysis showed no association when comparing systemic disease between mesh and control groups. Calculated risk ratio was 0.9 (95% CI 0.82-0.98). The fourth study was a case series with a high risk of bias, with a sample of 714 patients with systemic disease, 40 of whom had PP mesh implanted.
conclusionThere is no evidence to suggest a causal relationship between being implanted with a PP mesh and the occurrence of autoimmune disorders.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.