SynthesisEuropean journal of orthopaedic surgery & traumatology : orthopedie traumatologie2023
Influence of platelet-rich plasma (PRP) analogues on healing and clinical outcomes following anterior cruciate ligament (ACL) reconstructive surgery: a systematic review.
Synthesis in European journal of orthopaedic surgery & traumatology : orthopedie traumatologie, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 23 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Autologous platelet concentrate augmentation in anterior cruciate ligament reconstruction: a level I evidence-based meta-analysis.Orthopadie (Heidelberg, Germany) · 2026Pooled it
- The impact of platelet-rich plasma injection on anterior cruciate ligament reconstruction: a systematic review and meta-analysis.Frontiers in bioengineering and biotechnology · 2025Pooled it
- Effect of platelet-rich plasma on pain, function, and graft maturation after anterior cruciate ligament reconstruction: a prospective, randomized controlled trial.Scientific reports · 2026Trial
- Review
- Orthobiologics in anterior cruciate ligament injuries.Journal of experimental orthopaedics · 2026Review
- The effects of platelet-rich plasma therapy on outcomes after anterior cruciate ligament reconstruction: A systematic review and meta-analysis.Journal of experimental orthopaedics · 2026Review
- Type I Atelocollagen Interposition Within the ACL Graft During ACL Reconstruction: An Exploratory Clinical and MRI-Based Study.Medicina (Kaunas, Lithuania) · 2026Article
- Standardized Preparation and Multi-Site Application of Leukocyte-Poor Platelet-Rich Plasma in Arthroscopic Anterior Cruciate Ligament Reconstruction: A Technical Note with Early Functional Outcomes.Journal of orthopaedic case reports · 2026Article
- Role of Platelet-Rich Plasma Injection in Anterior Cruciate Ligament Reconstruction: A Meta-Analysis of Randomized Controlled Trials.Bioengineering (Basel, Switzerland) · 2026Article
- Platelet-Rich Plasma in Anterior Cruciate Ligament Reconstruction: An Updated Systematic Review and Meta-Analysis of Clinical and Radiological Outcomes.Journal of clinical medicine · 2026Review
- Intratendinous Normal Saline Injection of Quadriceps and Patellar Tendon Allografts Does Not Reduce Mechanical Strength at Time Zero.Arthroscopy, sports medicine, and rehabilitation · 2025Article
- Retrospective Study on the Efficacy of Platelet-Rich Plasma Treatment in the Recovery of Quadriceps Muscle Strength After Anterior Cruciate Ligament Reconstruction in Non-Professional Athletes.Journal of clinical medicine · 2025Article
- Platelet rich plasma and anterior cruciate ligament repair: A new frontier, or a short term adjunct.World journal of orthopedics · 2025Article
- Efficacy of Intraoperative Platelet-Rich Plasma After Meniscal Repair: Systematic Review and Meta-analysis.Indian journal of orthopaedics · 2024Review
- Clinical application of platelet rich plasma to promote healing of open hand injury with skin defect.Regenerative therapy · 2024Article
- Anterior Cruciate Ligament Reconstruction using Bone-Tendon-Bone Allograft: Surgical Technique Using Augmentation with Bio-Composite Scaffold.Arthroscopy techniques · 2024Article
- Severe mucoid degeneration of the anterior cruciate ligament (ACL) treated with conservative arthroscopic debridement and platelet-rich plasma (PRP) injection.BMJ case reports · 2024Article
- Neuraxial biomechanics, fluid dynamics, and myodural regulation: rethinking management of hypermobility and CNS disorders.Frontiers in neurology · 2024Review
- Anterior Cruciate Ligament Reconstruction With Quadriceps Tendon Autograft: Surgical Technique Using Augmentation With a Biocomposite Scaffold.Arthroscopy techniques · 2023Article
- Reconstruction of the anterior cruciate ligament: a historical view.Annals of translational medicine · 2023Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo systematically review the effect of PRP on healing (vascularization, inflammation and ligamentization) and clinical outcomes (pain, knee function and stability) in patients undergoing ACL reconstruction and compare the preparation and application of PRP.
methodsIndependent systematic searches of online databases (Medline, Embase and Web of Science) were conducted following PRISMA guidelines (final search 10th July 2021). Studies were screened against inclusion criteria and risk of bias assessed using Critical appraisal skills programme (CASP) Randomised controlled trial (RCT) checklist. Independent data extraction preceded narrative analysis.
results13 RCTs were included. The methods of PRP collection and application were varied. Significant early increases in rate of ligamentization and vascularisation were observed alongside early decreases in inflammation. No significant results were achieved in the later stages of the healing process. Significantly improved pain and knee function was found but no consensus reached.
conclusionsPRP influences healing through early vascularisation, culminating in higher rates of ligamentization. Long-term effects were not demonstrated suggesting the influence of PRP is limited. No consensus was reached on the impact of PRP on pain, knee stability and resultant knee function, providing avenues for further research. Subsequent investigations could incorporate multiple doses over time, more frequent observation and comparisons of different forms of PRP. The lack of standardisation of PRP collection and application techniques makes comparison difficult. Due to considerable heterogeneity, (I TRAIL REGISTRATION: CRD42021242078CRD, 15th March 2021, retrospectively registered.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.