Evidence map›Paper›PMID 35020021›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2022

Acute effects of ketamine on the pregenual anterior cingulate: linking spontaneous activation, functional connectivity, and glutamate metabolism.

Matti Gärtner, Anne Weigand, Milan Scheidegger, Mick Lehmann, Patrik O Wyss, Andreas Wunder, Anke Henning, Simone Grimm

Open access · hybridAbstract read
In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Detecting neuroplastic effects induced by ketamine in healthy human subjects: A multimodal approach.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2026
    Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Matti Gärtner *MSB Medical School Berlin, Rüdesheimer Straße 50, 14197, Berlin, Germany. matti.gaertner@medicalschool-berlin.de.
Anne Weigand *MSB Medical School Berlin, Rüdesheimer Straße 50, 14197, Berlin, Germany.
Milan ScheideggerDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland.
Mick LehmannDepartment of Psychiatry, Psychotherapy and Psychosomatics, University Hospital of Psychiatry, University of Zurich, Zurich, Switzerland.
Patrik O WyssDepartment of Radiology, Swiss Paraplegic Centre, Nottwil, Switzerland.
Andreas WunderTranslational Medicine and Clinical Pharmacology, Boehringer Ingelheim Pharma GmbH & Co. KG, 88397, Biberach an der Riss, Germany.
Anke HenningAdvanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, USA.
Simone GrimmMSB Medical School Berlin, Rüdesheimer Straße 50, 14197, Berlin, Germany.
MSB Medical School Berlin · DEUniversity of Zurich · CHBoehringer Ingelheim (Germany) · DESwiss Paraplegic Center · CHThe University of Texas Southwestern Medical Center · US

Funding

European Commission H2020-634541
6 · The paper itself

Abstract

Ketamine exerts its rapid antidepressant effects via modulation of the glutamatergic system. While numerous imaging studies have investigated the effects of ketamine on a functional macroscopic brain level, it remains unclear how altered glutamate metabolism and changes in brain function are linked. To shed light on this topic we here conducted a multimodal imaging study in healthy volunteers (N = 23) using resting state fMRI and proton (

Indexed as

Gyrus CinguliKetamineGlutamic AcidGlutamineHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyGlutamic AcidGlutamineKetamineGlutamateKetamineMR SpectroscopyResting state fMRI

Identifiers

PMID35020021
PMCPMC9095553
OpenAlexW4206009228

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.