Evidence map›Paper›PMID 35019769›Full record

Trial reportMicrobiology spectrum2022

The Impact of Mouthwash on the Oropharyngeal Microbiota of Men Who Have Sex with Men: a Substudy of the OMEGA Trial.

Erica L Plummer, Kate Maddaford, Gerald L Murray, Christopher K Fairley, Shivani Pasricha, Andre Mu, Catriona S Bradshaw, Deborah A Williamson, Eric P F Chow

Abstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Erica L PlummerCentre for Women's Infectious Diseases Research, The Royal Women's Hospital, Parkville, Victoria, Australia.ORCID 0000-0001-5710-2671
Kate MaddafordMelbourne Sexual Health Centre, Alfred Healthgrid.267362.4, Carlton, Victoria, Australia.
Gerald L MurrayCentre for Women's Infectious Diseases Research, The Royal Women's Hospital, Parkville, Victoria, Australia.ORCID 0000-0003-3330-4433
Christopher K FairleyCentral Clinical School, Monash University, Melbourne, Victoria, Australia.
Shivani PasrichaDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbournegrid.1008.9, Melbourne, Victoria, Australia.ORCID 0000-0001-9681-1956
Andre MuDepartment of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbournegrid.1008.9, Melbourne, Victoria, Australia.ORCID 0000-0002-0853-9743
Catriona S BradshawCentral Clinical School, Monash University, Melbourne, Victoria, Australia.
Deborah A Williamson *Department of Microbiology and Immunology, The Peter Doherty Institute for Infection and Immunity, The University of Melbournegrid.1008.9, Melbourne, Victoria, Australia.ORCID 0000-0001-7363-6665
Eric P F Chow *Central Clinical School, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0003-1766-0657

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mouthwash is a commonly used product and has been proposed as an alternative intervention to prevent gonorrhea transmission. However, the long-term effects of mouthwash on the oral microbiota are largely unknown. We investigated the impact of 12 weeks of daily mouthwash use on the oropharyngeal microbiota in a subset of men who have sex with men who participated in a randomized trial comparing the efficacy of two alcohol-free mouthwashes for the prevention of gonorrhea. We characterized the oropharyngeal microbiota using 16S rRNA gene sequencing of tonsillar fossae samples collected before and after 12 weeks of daily use of Listerine mouthwash or Biotène dry mouth oral rinse. Permutational multivariate analysis of variance (PERMANOVA) was used to assess differences in oropharyngeal microbiota composition following mouthwash use. Differential abundance testing was performed using ALDEx2, with false-discovery rate correction. A total of 306 samples from 153 men were analyzed (Listerine,

Indexed as

Homosexuality, MaleSexual and Gender MinoritiesAdultDouble-Blind MethodDrug CombinationsGlucose OxidaseGonorrheaHumansLactoperoxidaseMaleMicrobiotaMouthwashesMuramidaseOropharynxRNA, Ribosomal, 16SSalicylatesBioteneDrug CombinationsGlucose OxidaseLactoperoxidaseListerineMouthwashesMuramidaseRNA, Ribosomal, 16SSalicylatesTerpenesmen who have sex with menmouthwashNeisseria gonorrhoeaeoral microbiomeoropharyngeal gonorrhea

Identifiers

PMID35019769
PMCPMC8754113

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.