Evidence map›Paper›PMID 35019722›Full record

ArticleJournal of virology2022

Role of E6 in Maintaining the Basal Cell Reservoir during Productive Papillomavirus Infection.

Taylor Saunders-Wood, Nagayasu Egawa, Ke Zheng, Alberto Giaretta, Heather M Griffin, John Doorbar

Open access · hybridAbstract read
In one paragraph

Article in Journal of virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Taylor Saunders-Wood *Department of Pathology, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Nagayasu Egawa *Department of Pathology, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Ke ZhengDepartment of Pathology, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
Alberto GiarettaDepartment of Information Engineering, University of Padova, Padua, Italy.
Heather M GriffinDepartment of Pathology, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.
John DoorbarDepartment of Pathology, University of Cambridgegrid.5335.0, Cambridge, United Kingdom.ORCID 0000-0002-4027-102X
University of Cambridge · GBUniversity of Padua · IT

Funding

Cancer Research UK 28754Medical Research Council MC_PC_13050Medical Research Council MC_U117584278Medical Research Council MR/S024409/1Wellcome Trust
6 · The paper itself

Abstract

Papillomaviruses exclusively infect stratified epithelial tissues and cause chronic infections. To achieve this, infected cells must remain in the epithelial basal layer alongside their uninfected neighbors for years or even decades. To examine how papillomaviruses achieve this, we used the

Indexed as

Oncogene Proteins, ViralPapillomavirus InfectionsAnimalsCell DifferentiationEpitheliumKeratinocytesMiceNuclear ProteinsPapillomavirus E7 ProteinsTranscription FactorsE6 protein, human papillomavirus type 1Maml1 protein, mouseNuclear ProteinsOncogene Proteins, ViralPapillomavirus E7 ProteinsTranscription FactorsE6epithelial homeostasislesion formationlesion maintenancepapillomavirusproductive viral life cycle

Identifiers

PMID35019722
PMCPMC8906426
OpenAlexW4206073533

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.