Evidence map›Paper›PMID 35019217›Full record

ArticleAngewandte Chemie (International ed. in English)2022

Highly Efficient Polarizing Agents for MAS-DNP of Proton-Dense Molecular Solids.

Rania Harrabi, Thomas Halbritter, Fabien Aussenac, Ons Dakhlaoui, Johan van Tol, Krishna K Damodaran, Daniel Lee, Subhradip Paul, Sabine Hediger, Frederic Mentink-Vigier and 2 more

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

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  16. Characterization of dielectric properties and their impact on MAS-DNP NMR applications.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rania HarrabiUniv. Grenoble Alpes, CEA, CNRS, IRIG, MEM, 38000, Grenoble, France.ORCID 0000-0001-7981-5509
Thomas HalbritterUniversity of Iceland, Department of chemistry, Science Institute, Dunhaga 3, 107, Reykjavik, Iceland.ORCID 0000-0002-4642-0049
Fabien AussenacBruker Biospin, Wissembourg, France.ORCID 0000-0002-2599-7383
Ons DakhlaouiUniv. Grenoble Alpes, CEA, CNRS, IRIG, MEM, 38000, Grenoble, France.ORCID 0000-0002-8262-1761
Johan van TolNational High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32301, USA.
Krishna K DamodaranUniversity of Iceland, Department of chemistry, Science Institute, Dunhaga 3, 107, Reykjavik, Iceland.ORCID 0000-0002-9741-2997
Daniel LeeUniv. Grenoble Alpes, CEA, CNRS, IRIG, MEM, 38000, Grenoble, France.
Subhradip PaulUniv. Grenoble Alpes, CEA, CNRS, IRIG, MEM, 38000, Grenoble, France.
Sabine HedigerUniv. Grenoble Alpes, CEA, CNRS, IRIG, MEM, 38000, Grenoble, France.ORCID 0000-0001-5416-8405
Frederic Mentink-VigierNational High Magnetic Field Laboratory, Florida State University, Tallahassee, FL 32301, USA.ORCID 0000-0002-3570-9787
Snorri Th SigurdssonUniversity of Iceland, Department of chemistry, Science Institute, Dunhaga 3, 107, Reykjavik, Iceland.ORCID 0000-0003-2492-1456
Gaël De PaëpeUniv. Grenoble Alpes, CEA, CNRS, IRIG, MEM, 38000, Grenoble, France.

Funding

TR&D3-SCHP41GM122698 · NIGMS · FLORIDA STATE UNIVERSITY · PI BREY, WILLIAM W, CROSS, TIMOTHY A · 2017 to 2021
$6.7M
14.1 T magnet with +/-1280 G Field Regulation and Integrated MAS Cryogenic SystemS10OD018519 · OD · FLORIDA STATE UNIVERSITY · PI CROSS, TIMOTHY A · 2014 to 2014
$1.4M
NIGMS NIH HHS P41 GM122698NIH HHS S10 OD018519
6 · The paper itself

Abstract

Efficiently hyperpolarizing proton-dense molecular solids through dynamic nuclear polarization (DNP) solid-state NMR is still an unmet challenge. Polarizing agents (PAs) developed so far do not perform well on proton-rich systems, such as organic microcrystals and biomolecular assemblies. Herein we introduce a new PA, cAsymPol-POK, and report outstanding hyperpolarization efficiency on 12.76 kDa U-

Indexed as

ProtonsElectron Spin Resonance SpectroscopyMagnetic Resonance SpectroscopyPharmaceutical PreparationsPharmaceutical PreparationsProtonsBiomoleculesDynamic Nuclear PolarizationMAS-DNPNuclear Magnetic ResonancePharmaceuticalsPolarizing Agents

Identifiers

PMID35019217
PMCPMC8901535

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.