Evidence map›Paper›PMID 35019212›Full record

ArticleJournal of applied clinical medical physics2022

Quality assurance for on-table adaptive magnetic resonance guided radiation therapy: A software tool to complement secondary dose calculation and failure modes discovered in clinical routine.

Carolin Rippke, Oliver Schrenk, C Katharina Renkamp, Carolin Buchele, Juliane Hörner-Rieber, Jürgen Debus, Markus Alber, Sebastian Klüter

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
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  9. Article
  10. Article
  11. Article
  12. Clinical rationale forPhysics and imaging in radiation oncology · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carolin RippkeDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Baden-Wurttemberg, Germany.
Oliver SchrenkDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Baden-Wurttemberg, Germany.
C Katharina RenkampDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Baden-Wurttemberg, Germany.
Carolin BucheleDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Baden-Wurttemberg, Germany.
Juliane Hörner-RieberDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Baden-Wurttemberg, Germany.
Jürgen DebusDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Baden-Wurttemberg, Germany.
Markus AlberDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Baden-Wurttemberg, Germany.
Sebastian KlüterDepartment of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Baden-Wurttemberg, Germany.

Funding

German Research Foundation DFG DE 614/16-1
6 · The paper itself

Abstract

Online adaption of treatment plans on a magnetic resonance (MR)-Linac enables the daily creation of new (adapted) treatment plans using current anatomical information of the patient as seen on MR images. Plan quality assurance (QA) relies on a secondary dose calculation (SDC) that is required because a pretreatment measurement is impossible during the adaptive workflow. However, failure mode and effect analysis of the adaptive planning process shows a large number of error sources, and not all of them are covered by SDC. As the complex multidisciplinary adaption process takes place under time pressure, additional software solutions for pretreatment per-fraction QA need to be used. It is essential to double-check SDC input to ensure a safe treatment delivery. Here, we present an automated treatment plan check tool for adaptive radiotherapy (APART) at a 0.35 T MR-Linac. It is designed to complement the manufacturer-provided adaptive QA tool comprising SDC. Checks performed by APART include contour analysis, electron density map examinations, and fluence modulation complexity controls. For nine of 362 adapted fractions (2.5%), irregularities regarding missing slices in target volumes and organs at risks as well as in margin expansion of target volumes have been found. This demonstrates that mistakes occur and can be detected by additional QA measures, especially contour analysis. Therefore, it is recommended to implement further QA tools additional to what the manufacturer provides to facilitate an informed decision about the quality of the treatment plan.

Indexed as

Radiotherapy, Image-GuidedRadiotherapy, Intensity-ModulatedHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyParticle AcceleratorsRadiotherapy DosageRadiotherapy Planning, Computer-AssistedSoftwareadaptive radiotherapyfailure mode and effect analysis (FMEA)image-guided radiotherapyMR-guided radiation therapyonline adaptiveon-table adaptivequality assurancerisk management

Identifiers

PMID35019212
PMCPMC8906229

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.