Evidence map›Paper›PMID 35019167›Full record

ArticleNeurourology and urodynamics2022

Incomplete bladder emptying and urinary tract infections after botulinum toxin injection for overactive bladder: Multi-institutional collaboration from the SUFU research network.

William Stuart Reynolds, Anne M Suskind, Jennifer T Anger, Benjamin M Brucker, Anne P Cameron, Doreen E Chung, Stephanie Daignault-Newton, Giulia I Lane, Alvaro Lucioni, Arthur P Mourtzinos and 6 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurourology and urodynamics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 1 country.

William Stuart ReynoldsDivision of Reconstructive Urology and Pelvic Health, Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-3444-1421
Anne M SuskindDepartment of Urology, University of California San Francisco, San Francisco, California, USA.ORCID 0000-0002-8437-3861
Jennifer T AngerDepartment of Urology, UC San Diego Health, San Diego, California, USA.ORCID 0000-0002-7688-4688
Benjamin M BruckerDepartment of Urology, New York University, Langone Health, New York, New York, USA.
Anne P CameronDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Doreen E ChungDepartment of Urology, Columbia University Irving Medical Center, New York, New York, USA.
Stephanie Daignault-NewtonDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.
Giulia I LaneDepartment of Urology, University of Michigan, Ann Arbor, Michigan, USA.ORCID 0000-0002-6977-5280
Alvaro LucioniVirginia Mason Medical Center, Seattle, Washington, USA.
Arthur P MourtzinosDepartment of Urology, Lahey Hospital & Medical Center, Burlington, Massachusetts, USA.
Priya PadmanabhanDepartment of Urology, Beaumont Health, Farmington Hills, Michigan, USA.
Polina X ReyblatKaiser Permanente, Los Angeles, California, USA.
Ariana L SmithDivision of Urology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.ORCID 0000-0002-9784-2559
Christopher F TenggardjajaKaiser Permanente, Los Angeles, California, USA.
Una J LeeVirginia Mason Medical Center, Seattle, Washington, USA.ORCID 0000-0003-1128-5083
SUFU Research Network
University of Michigan · USKaiser Permanente · USVirginia Mason Medical Center · USBeaumont Health · USColumbia University Irving Medical Center · USLahey Medical Center · USNYU Langone Health · USUC San Diego Health System · USUniversity of California, San Francisco · USUniversity of Pennsylvania · USVanderbilt University Medical Center · US

Funding

Michigan Institute for Clinical and Health Research (MICHR)UL1TR002240 · NCATS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LUMENG, JULIE C, MASHOUR, GEORGE ALEXANDER · 2017 to 2022
$54.9M
University of Michigan UroEPI Career Development ProgramK12DK111011 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CLEMENS, J. QUENTIN, SARMA, ARUNA V · 2016 to 2025
$3.6M
NCATS NIH HHS UL1 TR002240NIDDK NIH HHS K12 DK111011
6 · The paper itself

Abstract

introductionOnabotulinumtoxin A (BTX-A) is an effective therapy for overactive bladder (OAB), however, adverse events may prevent patients from initiating therapy. The study objective was to report real-world rates of incomplete emptying and urinary tract infection (UTI) in men and women undergoing BTX-A for OAB.

methodsEleven clinical sites performed a retrospective study of adults undergoing first-time BTX-A injection (100 units) for idiopathic OAB in 2016. Exclusions included: postvoid residual (PVR) > 150 ml, prior BTX-A, pelvic radiation, or need for preprocedure catheterization. Primary outcomes at 6 months were incomplete emptying (clean intermittent catheterization [CIC] or PVR ≥ 300 ml without the need for CIC); and UTI (symptoms with either positive culture or urinalysis or empiric treatment). We compared rates of incomplete emptying and UTI within and between sexes, using univariate and multivariable models.

results278 patients (48 men and 230 women) met inclusion criteria. Mean age was 65.5 years (range: 24-95). 35% of men and 17% of women had incomplete emptying. Men had 2.4 (95% CI: 1.04-5.49) higher odds of incomplete emptying than women. 17% of men and 23.5% of women had ≥1 UTI, the majority of which occurred within the first month following injection. The strongest predictor of UTI was a history of prior UTI (OR: 4.2 [95% CI: 1.7-10.3]).

conclusionsIn this multicenter retrospective study, rates of incomplete emptying and UTI were higher than many previously published studies. Men were at particular risk for incomplete emptying. Prior UTI was the primary risk factor for postprocedure UTI.

Indexed as

Botulinum Toxins, Type AUrinary Bladder, OveractiveUrinary RetentionUrinary Tract InfectionsAdultAgedFemaleHumansMaleRepressor ProteinsRetrospective StudiesUrinary BladderBotulinum Toxins, Type ARepressor ProteinsSUFU protein, humancomplicationsoveractive bladderretentionurinary tract infection

Identifiers

PMID35019167
PMCPMC8891079
OpenAlexW4205828245

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.