ArticleeLife2022
Metabolic sensing in AgRP neurons integrates homeostatic state with dopamine signalling in the striatum.
Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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Who cites it
28 citing papers in PubMed, 61 citations in OpenAlex.
- Liraglutide restores impaired associative learning in individuals with obesity.Nature metabolism · 2023Trial
- Brain responses to nutrients are severely impaired and not reversed by weight loss in humans with obesity: a randomized crossover study.Nature metabolism · 2023Trial
- Reduced melanocortin tone modulates feeding during pregnancy in mice.Nature communications · 2026Article
- Altered responses to ghrelin and food cues in AgRP neurons during pregnancy and lactation.Journal of neuroendocrinology · 2026Article
- The development of FEDUPP: feeding experimentation device users processing package to assess learning and cognitive flexibility.Translational psychiatry · 2026Article
- Mesolimbic dopamine signaling mediates increased hedonic feeding and food seeking in lactating mice.bioRxiv : the preprint server for biology · 2026Article
- Glucose levels are associated with mood, but the association is mediated by ratings of metabolic state.EBioMedicine · 2026Observational
- Brain Nutrient Sensing: A Unifying Framework.Annual review of physiology · 2026Review
- Prefrontal cortex-to-hypothalamic outputs orchestrate cue-potentiated palatable food consumption via AMPKβ2 signaling.Cell discovery · 2026Article
- Need-selective gating of dopamine neuron cue responses by real and virtual hunger.bioRxiv : the preprint server for biology · 2025Article
- Fat sensory cues in early life program central response to food and obesity.Nature metabolism · 2025Article
- GHSRs in the olfactory bulb suppress food motivation and promote exploration without altering spatial memory in male mice.Journal of neuroendocrinology · 2025Article
- Article
- Elevated activity of the mesolimbic dopamine system promotes feeding during pregnancy in mice.bioRxiv : the preprint server for biology · 2025Article
- The interoceptive origin of reinforcement learning.Trends in cognitive sciences · 2025Review
- Striatal dopamine tone is positively associated with adiposity in humans as determined by PET using dual dopamine type-2 receptor antagonist tracers.Molecular psychiatry · 2025Article
- Article
- Molecular and functional mapping of the neuroendocrine hypothalamus: a new era begins.Journal of endocrinological investigation · 2024Review
- Hypothalamic AgRP neurons regulate the hyperphagia of lactation.Molecular metabolism · 2024Article
- Is There a Natural, Non-addictive, and Non-anti-reward, Safe, Gene-based Solution to Treat Reward Deficiency Syndrome? KB220 Variants vs GLP-1 Analogs.Journal of addiction psychiatry · 2024Article
Corrections and comments
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Authors and funding
18 authors at 7 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Agouti-related peptide (AgRP) neurons increase motivation for food, however, whether metabolic sensing of homeostatic state in AgRP neurons potentiates motivation by interacting with dopamine reward systems is unexplored. As a model of impaired metabolic-sensing, we used the AgRP-specific deletion of carnitine acetyltransferase (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.