Evidence map›Paper›PMID 35018784›Full record

ArticleEnvironmental science & technology2022

Identification of Novel Microcystins Using High-Resolution MS and MS

David Baliu-Rodriguez, Nicholas J Peraino, Sanduni H Premathilaka, Johnna A Birbeck, Tomás Baliu-Rodriguez, Judy A Westrick, Dragan Isailovic

Open access · greenAbstract read
In one paragraph

Article in Environmental science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
8.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 81 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

David Baliu-RodriguezDepartment of Chemistry and Biochemistry, University of Toledo, Toledo, Ohio 43606, United States.
Nicholas J PerainoDepartment of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.
Sanduni H PremathilakaDepartment of Chemistry and Biochemistry, University of Toledo, Toledo, Ohio 43606, United States.
Johnna A BirbeckDepartment of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.
Tomás Baliu-RodriguezDepartment of Geography, Ohio State University, Columbus, Ohio 43210, United States.
Judy A WestrickDepartment of Chemistry, Wayne State University, Detroit, Michigan 48202, United States.
Dragan IsailovicDepartment of Chemistry and Biochemistry, University of Toledo, Toledo, Ohio 43606, United States.ORCID 0000-0002-1094-7738
University of Toledo · USWayne State University · USThe Ohio State University · US

Funding

Research Experience & Training Coordination CoreP42ES030991 · NIEHS · WAYNE STATE UNIVERSITY · PI Judy A Westrick · 2022 to 2026
$13.9M
Pilot Project ProgramP30ES020957 · NIEHS · WAYNE STATE UNIVERSITY · PI RUNGE-MORRIS, MELISSA A · 2014 to 2021
$10.1M
Translational Research Support CoreP30ES036084 · NIEHS · WAYNE STATE UNIVERSITY · PI Melissa A Runge-Morris · 2024 to 2026
$5.2M
NIEHS NIH HHS P30 ES020957NIEHS NIH HHS P30 ES036084NIEHS NIH HHS P42 ES030991
6 · The paper itself

Abstract

Cyanotoxins called microcystins (MCs) are highly toxic and can be present in drinking water sources. Determining the structure of MCs is paramount because of its effect on toxicity. Though over 300 MC congeners have been discovered, many remain unidentified. Herein, a method is described for the putative identification of MCs using liquid chromatography (LC) coupled with high-resolution (HR) Orbitrap mass spectrometry (MS) and a new bottom-up sequencing strategy. Maumee River water samples were collected during a harmful algal bloom and analyzed by LC-MS with simultaneous HRMS and MS/MS. Unidentified ions with characteristic MC fragments (135 and 213

Indexed as

MicrocystinsTandem Mass SpectrometryChromatography, LiquidFresh WaterHarmful Algal BloomMicrocystinshigh-resolution mass spectrometrymicrocystinsMSnPython softwarestructural identification

Identifiers

PMID35018784
PMCPMC12989180
OpenAlexW4205632882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.