Evidence map›Paper›PMID 35018500›Full record

ArticleClinical oral investigations2022

Interdental biofilm reduction and composition after use of an activated and inactivated side-to-side toothbrush - a proof-of-principle clinical study.

Julia C Difloe-Geisert, Sarah Fiedler, Eva M Kulik, Nadine Schlueter, Carolina Ganss, Clemens Walter

Abstract readClinical Study
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Julia C Difloe-GeisertDepartment of Periodontology, Endodontology and Cariology, University Center for Dental Medicine Basel (UZB), University of Basel, Mattenstrasse 40, 4058, Basel, Switzerland. julia.schmidt@unibas.ch.
Sarah FiedlerDivision for Cariology, Department of Operative Dentistry and Periodontology, Center for Dental Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany.
Eva M KulikDepartment Research, University Center for Dental Medicine Basel (UZB), University of Basel, Basel, Switzerland.
Nadine SchlueterDivision for Cariology, Department of Operative Dentistry and Periodontology, Center for Dental Medicine, Medical Center University of Freiburg, University of Freiburg, Freiburg, Germany.
Carolina GanssDepartment of Conservative and Preventive Dentistry, Dental Clinic, Justus Liebig University, Giessen, Germany.
Clemens WalterDepartment of Restorative Dentistry, Periodontology, Endodontology, and Preventive and Pediatric Dentistry, University Medicine Greifswald, Greifswald, Germany.
University of Basel · CHUniversity of Freiburg · DEJustus-Liebig-Universität Gießen · DEUniversitätsmedizin Greifswald · DE

Funding

Schweizerische Zahnärzte-Gesellschaft 304-18
6 · The paper itself

Abstract

objectivesTo evaluate interdental biofilm reduction and composition after powered toothbrushing with a side-to-side (sonic) toothbrush compared to manual toothbrushing following single brushing exercises in periodontally healthy young adults. MATERIALS AND

methodsAll participants brushed with a side-to-side toothbrush without toothpaste in four different modes: toothbrush (a) inactivated without instruction (OFF-NI), (b) activated without instruction (ON-NI), (c) inactivated with instruction (OFF-I), and (d) activated with instruction (ON-I) at consecutive visits (single brushing exercises). Before and after brushing, the Approximal Plaque Index (API) was assessed at three interdental spaces and plaque samples were taken from two interdental sites. Biofilm reduction and composition were analyzed microbiologically by total bacterial load and 16S rRNA sequencing.

resultsThirty participants (age: 22.9 ± 2.5 years) completed the study. Most participants showed no or incomplete plaque removal assessed by API following single brushing exercises, while the frequency of API reduction was higher after ON-NI compared to OFF-I (p = 0.023). Irrespective of the brushing mode, a significant reduction of total bacterial load was detected with lower bacterial counts after OFF-NI compared to ON-NI (p = 0.008) and ON-I (p = 0.007). Biofilm composition showed slight changes in the relative abundances of bacterial taxa, regardless of the brushing mode.

conclusionsManual and powered toothbrushing with a side-to-side toothbrush, with and without instruction, showed incomplete interdental biofilm removal in periodontally healthy young adults following single brushing exercises. CLINICAL RELEVANCE: Data has to be validated in further studies on other groups, however, in periodontally healthy young adults, additional devices seem to be necessary for sufficient interdental cleaning.

Indexed as

BiofilmsToothbrushingAdultDental Plaque IndexEquipment DesignHumansRNA, Ribosomal, 16SYoung AdultRNA, Ribosomal, 16SBiofilmClinical studyOral hygieneSide-to-side toothbrushToothbrushing

Identifiers

PMID35018500
OpenAlexW4206155915

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.