ArticleJournal of pharmacy & bioallied sciences2021
Prevalence of Titanium Hypersensitivity in Patients with Titanium Implants: A Systematic Review and Meta-analysis.
Article in Journal of pharmacy & bioallied sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Effects of clindamycin and amoxycillin as prophylaxis against early implant failure: double-blinded randomized clinical trial.Clinical oral investigations · 2024Trial
- Fused filament fabrication of radiopaque barium sulfate-reinforced polyetheretherketone composites for thin-walled patient-specific orbital reconstruction.Journal of materials science. Materials in medicine · 2026Article
- In vitro analysis of a glass solder matrix on ATZ-ceramic-samples using human dental pulp cells and L929 mouse fibroblasts.International journal of implant dentistry · 2026Article
- Clinical and Radiographic Evaluation of Effect of Ellagic Acid on Osseointegration Around Dental Implants: An Original Research.Journal of pharmacy & bioallied sciences · 2025Article
- Assessment of Complications in Dental Implant Surgery.Journal of pharmacy & bioallied sciences · 2024Article
- Evaluation of Failure in Single-Piece Implant Systems: A One-Year Follow-Up Study.Journal of pharmacy & bioallied sciences · 2024Article
- Are Allergy-Induced Implant Failures Actually Hypersensitivity Reactions to Titanium? A Literature Review.Dentistry journal · 2023Review
- Surface Treatments of PEEK for Osseointegration to Bone.Biomolecules · 2023Review
- Silica coated high performance oxide ceramics promote greater ossification than titanium implants: an in vivo study.Journal of orthopaedic surgery and research · 2023Article
- Orthopedic implant hypersensitivity: Characterization of clinical presentation and effects of photobiomodulation therapy.Tzu chi medical journalArticle
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWith increase in exposure to titanium in daily life and its use in medical procedures, there is a greater chance for developing titanium hypersensitivity. Our aim and objective is to examine whether patient patients with titanium implants had a greater incidence of titanium hypersensitivity or not. Titanium is widely considered to have good biocompatibility. A passivating surface layer of TiO MATERIALS AND
methodsOnly case-control studies were used for the meta-analysis. Studies with a sample size of <5 were excluded. Cutaneous and epicutaneous tests were used in the study.
resultsThree studies met the inclusion criteria. Titanium hypersensitivity is more prevalent in patients with titanium implants.
conclusionsIt is also used in a variety of medical devices such as pacemakers and insulin pumps. Moreover, our external exposure to titanium is increasing. It is used in aerospace, chemical, and automobile industries. It is also used in jewelry, home furnishings, and in making sports and marine equipment. Titanium implants increase the possibility of developing titanium hypersensitivity, and thus, it should be considered as a major factor in unexplained implant failure where other causes have been excluded.
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Registered trials
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