Evidence map›Paper›PMID 35017774›Full record

Trial reportIranian journal of medical sciences2022

The Comparison of the Efficacy of Early versus Late Administration of Dexmedetomidine on Postoperative Emergence Agitation in Children Undergoing Oral Surgeries: A Randomized Clinical Trial.

Afsaneh Sadeghi, Seyed Sajad Razavi, Ahmad Eghbali, Seyed Alireza Mahdavi, Fereshteh Kimia, Ashkan Panah

Registry-linked trialOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Iranian journal of medical sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07557576 (Comparison of Impact of Opioid and Non-Opioid Anesthesia on Pain and Agitation Levels in Children After Cleft Lip and Palate Surgery), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07557576 narecruitingnot on this mapstarted 2024, after this paper: background citation

Comparison of Impact of Opioid and Non-Opioid Anesthesia on Pain and Agitation Levels in Children After Cleft Lip and Palate Surgery

TypeinterventionalSponsorIva SmiljanićRan2024 to 2026Enrolled90ConditionsCleft Lip Palate, Orofacial Cleft, Agitation, Emergence, Analgesia AssessmentArmsKetamine (1 mg/kg), Dexmedetomidine (1-0,8-0,6-0,4 mcg/kg/h), Fentanyl 5 mcg/kg, Propofol (IV) 3-4 mg/kg, Sevoflurane (Volatile Anesthetic)
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Afsaneh SadeghiAnesthesia Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Sajad RazaviAnesthesia Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ahmad EghbaliAnesthesia Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyed Alireza MahdaviAnesthesia Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fereshteh KimiaAnesthesia Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ashkan PanahAnesthesiology and Critical Care Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Shahid Beheshti University of Medical Sciences · IRShiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEmergence Agitation (EA) is a dissociated state of consciousness characterized by irritability, uncompromising stance, and inconsolability. The etiology of EA is not completely understood. Dexmedetomidine is a highly selective α

methodsA randomized, parallel, double-blind clinical trial was conducted at Mofid Children's Hospital affiliated to Shahid Beheshti University of Medical Sciences (Tehran, Iran) from November 2016 to March 2017. A total of 81 children, who underwent adenotonsillectomy or cleft palate repair surgery were enrolled in the study. Based on simple randomization, the children were assigned to two groups, namely early (group A, n=41) and late (group B, n=40) administration of dexmedetomidine. Intra-operative and postoperative hemodynamic variables, extubation time, post-anesthesia care unit (PACU) length of stay, and the scores on Ramsay sedation scale and FLACC pain scale were measured and compared. The data were analyzed using SPSS software (version 20.0), and P<0.05 were considered statistically significant.

resultsThe mean FLACC score was lower in the late group than in the early group (2.0±1.5 vs. 4.2±1.6, P<0.001). The mean Ramsay sedation score was higher in the late group than in the early group (3.5±1.4 vs. 1.8±0.8, P<0.001).

conclusionLate administration of dexmedetomidine 1 µg/kg reduced the incidence of EA and PACU length of stay and improved postoperative pain management. TRIAL REGISTRATION NUMBER: IRCT 2016122031497N1.

Indexed as

DexmedetomidineEmergence DeliriumOral Surgical ProceduresAnesthesia Recovery PeriodChildDouble-Blind MethodHumansIranPsychomotor AgitationDexmedetomidineCleft palateDelayed emergence from anesthesiaDexmedetomidineEmergence deliriumTonsillectomy

Identifiers

PMID35017774
PMCPMC8743374
OpenAlexW3164301640

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.