ArticleCommunications biology2022
Independent control of amplitude and period in a synthetic oscillator circuit with modified repressilator.
Article in Communications biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Self-Oscillatory Neuron-like Devices for Unconventional Computing Applications.Chemical reviews · 2026Review
- Temporal gene regulation enables controlled expression of gas vesicles and preserves bacterial viability.Nature communications · 2025Article
- Intracellularly coupled oscillators for synthetic biology.Nature communications · 2025Review
- A tool for modeling gene regulatory networks (GRN_modeler) and its applications to synthetic biology.Molecular systems biology · 2025Article
- Engineering plant holobionts for climate-resilient agriculture.The ISME journal · 2025Review
- A mathematical framework for measuring and tuning tempo in developmental gene regulatory networks.Development (Cambridge, England) · 2024Article
- The dynamic-process characterization and prediction of synthetic gene circuits by dynamic delay model.iScience · 2024Article
- An oscillating reaction network with an exact closed form solution in the time domain.BMC bioinformatics · 2023Article
- Bacterial degrons in synthetic circuits.Open biology · 2022Review
- Microfluidics for long-term single-cell time-lapse microscopy: Advances and applications.Frontiers in bioengineering and biotechnology · 2022Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Synthetic Biology aims to create predictable biological circuits and fully operational biological systems. Although there are methods to create more stable oscillators, such as repressilators, independently controlling the oscillation of reporter genes in terms of their amplitude and period is only on theoretical level. Here, we introduce a new oscillator circuit that can be independently controlled by two inducers in Escherichia coli. Some control components, including σECF11 and NahR, were added to the circuit. By systematically tuning the concentration of the inducers, salicylate and IPTG, the amplitude and period can be modulated independently. Furthermore, we constructed a quantitative model to forecast the regulation results. Under the guidance of the model, the expected oscillation can be regulated by choosing the proper concentration combinations of inducers. In summary, our work achieved independent control of the oscillator circuit, which allows the oscillator to be modularized and used in more complex circuit designs.
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Registered trials
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