Evidence map›Paper›PMID 35017604›Full record

SynthesisScientific reports2022

A systematic review and meta-analysis of the catastrophic costs incurred by tuberculosis patients.

Ramy Mohamed Ghazy, Haider M El Saeh, Shaimaa Abdulaziz, Esraa Abdellatif Hammouda, Amira Mohamed Elzorkany, Heba Khidr, Nardine Zarif, Ehab Elrewany, Samar Abd ElHafeez

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
66citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

66 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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  18. Effect of Poverty and Rural Settings on Catastrophic Expenditure in Multi-Drug-Resistant Tuberculosis: An Exploratory Study using Propensity Score Matching.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine · 2025
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  19. Article
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6 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ramy Mohamed GhazyTropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt.ORCID http://orcid.org/0000-0001-7611-706X
Haider M El SaehCommunity Medicine Department, Faculty of Medicine, University of Tripoli, Tripoli, Libya.ORCID http://orcid.org/0000-0003-1031-0777
Shaimaa AbdulazizMinistry of Health and Population, Alexandria, Egypt.ORCID http://orcid.org/0000-0002-9197-6396
Esraa Abdellatif HammoudaMinistry of Health and Population, Alexandria, Egypt.ORCID http://orcid.org/0000-0003-3269-6623
Amira Mohamed ElzorkanyMinistry of Health and Population, Alexandria, Egypt. hiph.amiraelzorkany@alexu.edu.eg.ORCID http://orcid.org/0000-0001-8572-1285
Heba KhidrMinistry of Health and Population, Alexandria, Egypt.ORCID http://orcid.org/0000-0003-3929-7705
Nardine ZarifMinistry of Health and Population, Alexandria, Egypt.ORCID http://orcid.org/0000-0002-0676-6109
Ehab ElrewanyTropical Health Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt.ORCID http://orcid.org/0000-0002-8700-0630
Samar Abd ElHafeezEpidemiology Department, High Institute of Public Health, Alexandria University, Alexandria, Egypt.ORCID http://orcid.org/0000-0002-3250-2780

Funding

World Health Organization partially funded by WHO-TDR (SGS 20-28)
6 · The paper itself

Abstract

One of the strategies of the World Health Organization End Tuberculosis (TB) was to reduce the catastrophic costs incurred by TB-affected families to 0% by 2020.Catastrophic cost is defined by the total cost related to TB management exceeding 20% of the annual pre-TB household income. This study aimed to estimate the pooled proportion of TB affected households who incurred catastrophic costs. We searched PubMed, SciELO, Scopus, Embase, Google Scholar, ProQuest, SAGE, and Web of Science databases according to Preferred Reporting Items of the Systematic Reviews and Meta-Analysis (PRISMA) guidelines till November 20, 2020. Eligible studies were identified and data on catastrophic costs due to TB were extracted. We performed a meta-analysis to generate the pooled proportion of patients with TB facing catastrophic costs. From 5114 studies identified, 29 articles were included in the final analysis. The pooled proportion of patients faced catastrophic costs was (43%, 95% CI [34-51]). Meta-regression revealed that country, drug sensitivity, and Human immune-deficiency Virus (HIV) co-infection were the main predictors of such costs. Catastrophic costs incurred by drug sensitive, drug resistant, and HIV co-infection were 32%, 81%, and 81%, respectively. The catastrophic costs incurred were lower among active than passive case findings (12% vs. 30%). Half (50%) of TB-affected households faced catastrophic health expenditure at 10% cut-off point. The financial burden of patients seeking TB diagnosis and treatment continues to be a worldwide impediment. Therefore, the End TB approach should rely on socioeconomic support and cost-cutting initiatives.PROSPERO registration: CRD42020221283.

Indexed as

TuberculosisCost of IllnessHealth Care CostsHealth ExpendituresHIV InfectionsHumans

Identifiers

PMID35017604
PMCPMC8752613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.