Evidence map›Paper›PMID 35017578›Full record

ArticleScientific reports2022

KIBRA, MTNR1B, and FKBP5 genotypes are associated with decreased odds of incident delirium in elderly post-surgical patients.

Mark Terrelonge, Sara C LaHue, Christopher Tang, Irina Movsesyan, Clive R Pullinger, Dena B Dubal, Jacqueline Leung, Vanja C Douglas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Review
  7. A Molecular Framework for Delirium.The Neurohospitalist · 2024
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Mark Terrelonge *Department of Neurology, School of Medicine, University of California, San Francisco, CA, USA.
Sara C LaHue *Department of Neurology, School of Medicine, University of California, San Francisco, CA, USA. sara.lahue@ucsf.edu.
Christopher TangDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
Irina MovsesyanCardiovascular Research Institute, University of California, San Francisco, CA, USA.
Clive R PullingerCardiovascular Research Institute, University of California, San Francisco, CA, USA.
Dena B DubalDepartment of Neurology, School of Medicine, University of California, San Francisco, CA, USA.
Jacqueline LeungDepartment of Anesthesia and Perioperative Care, University of California, San Francisco, CA, USA.
Vanja C DouglasDepartment of Neurology, School of Medicine, University of California, San Francisco, CA, USA.
University of California, San Francisco · US

Funding

VARC CoreP30AG044281 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Louise C. Walter · 2013 to 2026
$19.9M
The role of genomics in postoperative delirium and sedationR01NR017622 · NINR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LEUNG, JACQUELINE M · 2019 to 2021
$2.6M
Klotho and Neurodegenerative DiseaseR01NS092918 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBAL, DENA BOU · 2016 to 2020
$1.7M
Biological signatures of neurodegeneration and aging associated with delirium in older adults following hip fracture surgeryR03AG074035 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAHUE, SARA CATHERINE · 2021 to 2022
$323k
Larry L. Hillblom Foundation A137420NIA NIH HHS P30 AG044281NIA NIH HHS R03 AG074035NIA NIH HHS R03AG074035NIH HHS NS092918NIH HHS RO1NR017622NINR NIH HHS R01 NR017622
6 · The paper itself

Abstract

Despite the association between cognitive impairment and delirium, little is known about whether genetic differences that confer cognitive resilience also confer resistance to delirium. To investigate whether older adults without postoperative delirium, compared with those with postoperative delirium, are more likely to have specific single nucleotide polymorphisms (SNPs) in the FKBP5, KIBRA, KLOTHO, MTNR1B, and SIRT1 genes known to be associated with cognition or delirium. This prospective nested matched exploratory case-control study included 94 older adults who underwent orthopedic surgery and screened for postoperative delirium. Forty-seven subjects had incident delirium, and 47 age-matched controls were not delirious. The primary study outcome was genotype frequency for the five SNPs. Compared with participants with delirium, those without delirium had higher adjusted odds of KIBRA SNP rs17070145 CT/TT [vs. CC; adjusted odds ratio (aOR) 2.80, 95% confidence interval (CI) 1.03, 7.54; p = 0.04] and MTNR1B SNP rs10830963 CG/GG (vs. CC; aOR 4.14, 95% CI 1.36, 12.59; p = 0.01). FKBP5 SNP rs1360780 CT/TT (vs. CC) demonstrated borderline increased adjusted odds of not developing delirium (aOR 2.51, 95% CI 1.00, 7.34; p = 0.05). Our results highlight the relevance of KIBRA, MTNR1B, and FKBP5 in understanding the complex relationship between delirium, cognition, and sleep, which warrant further study in larger, more diverse populations.

Indexed as

DeliriumGenotypePolymorphism, Single NucleotidePostoperative ComplicationsReceptor, Melatonin, MT2Tacrolimus Binding ProteinsAgedAged, 80 and overCase-Control StudiesFemaleGenetic Predisposition to DiseaseHumansIntracellular Signaling Peptides and ProteinsMaleProspective StudiesTacrolimus Binding Protein 5Intracellular Signaling Peptides and ProteinsMTNR1B protein, humanReceptor, Melatonin, MT2Tacrolimus Binding Protein 5Tacrolimus Binding ProteinsWWC1 protein, human

Identifiers

PMID35017578
PMCPMC8752781
OpenAlexW4205502998

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.