Evidence map›Paper›PMID 35017568›Full record

Observational studyScientific reports2022

Prone versus supine free-breathing for right-sided whole breast radiotherapy.

Odile Fargier-Bochaton, Xinzhuo Wang, Giovanna Dipasquale, Mohamed Laouiti, Melpomeni Kountouri, Olena Gorobets, Nam P Nguyen, Raymond Miralbell, Vincent Vinh-Hung

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02237469 (Retrospective Dosimetric Study of Prone Radiotherapy for Breast Cancer), which is not on this map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02237469 unknown statusnot on this map

Retrospective Dosimetric Study of Prone Radiotherapy for Breast Cancer

TypeobservationalSponsorVincent Vinh-HungRan2010 to 2023Enrolled280ConditionsBreast Cancer FemaleArmsProne and supine simulation
3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Dosimetric advantage of ipsilateral lung and cardiac sparing of left breast cancer prone position compared with supine free breathing in the COVID-19 era and personalized medicine.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Odile Fargier-BochatonRadiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland.
Xinzhuo WangRadiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland.
Giovanna DipasqualeRadiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland.
Mohamed LaouitiRadiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland.
Melpomeni KountouriRadiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland.
Olena GorobetsCHU de Martinique, Fort-de-France, Martinique, France.
Nam P NguyenRadiation Oncology, Howard University, Washington, DC, USA.
Raymond MiralbellRadiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland. raymond.miralbell@unige.ch.
Vincent Vinh-HungRadiation Oncology Department, Geneva University Hospitals, Geneva, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prone setup has been advocated to improve organ sparing in whole breast radiotherapy without impairing breast coverage. We evaluate the dosimetric advantage of prone setup for the right breast and look for predictors of the gain. Right breast cancer patients treated in 2010-2013 who had a dual supine and prone planning were retrospectively identified. A penalty score was computed from the mean absolute dose deviation to heart, lungs, breasts, and tumor bed for each patient's supine and prone plan. Dosimetric advantage of prone was assessed by the reduction of penalty score from supine to prone. The effect of patients' characteristics on the reduction of penalty was analyzed using robust linear regression. A total of 146 patients with right breast dual plans were identified. Prone compared to supine reduced the penalty score in 119 patients (81.5%). Lung doses were reduced by 70.8%, from 4.8 Gy supine to 1.4 Gy prone. Among patient's characteristics, the only significant predictors were the breast volumes, but no cutoff could identify when prone would be less advantageous than supine. Prone was associated with a dosimetric advantage in most patients. It sets a benchmark of achievable lung dose reduction.Trial registration: ClinicalTrials.gov NCT02237469, HUGProne, September 11, 2014, retrospectively registered.

Indexed as

Breast NeoplasmsRadiotherapy DosageAdultAgedBreastFemaleHumansLungMiddle AgedOrgans at RiskPatient PositioningProne PositionRadiotherapy Planning, Computer-AssistedRespirationRetrospective StudiesSupine Position

Identifiers

PMID35017568
PMCPMC8752750

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.