Evidence map›Paper›PMID 35017528›Full record

ArticleNature communications2022

The RNA methyltransferase METTL8 installs m

Nicole Kleiber, Nicolas Lemus-Diaz, Carina Stiller, Marleen Heinrichs, Mandy Mong-Quyen Mai, Philipp Hackert, Ricarda Richter-Dennerlein, Claudia Höbartner, Katherine E Bohnsack, Markus T Bohnsack

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 1 pooled it
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
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  16. Endonuclease G promotes hepatic mitochondrial respiration by selectively increasing mitochondrial tRNAProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  17. Article
  18. Structural basis of tRNA recognition by the mNature structural & molecular biology · 2024
    Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Nicole Kleiber *Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.ORCID http://orcid.org/0000-0003-0844-7547
Nicolas Lemus-Diaz *Department of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.
Carina Stiller *Institute of Organic Chemistry, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.ORCID http://orcid.org/0000-0002-2534-7102
Marleen HeinrichsDepartment of Cellular Biochemistry, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.
Mandy Mong-Quyen MaiDepartment of Cellular Biochemistry, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.
Philipp HackertDepartment of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.
Ricarda Richter-DennerleinDepartment of Cellular Biochemistry, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany.ORCID http://orcid.org/0000-0001-8904-1543
Claudia HöbartnerInstitute of Organic Chemistry, Universität Würzburg, Am Hubland, 97074, Würzburg, Germany.ORCID http://orcid.org/0000-0002-4548-2299
Katherine E BohnsackDepartment of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany. katherine.bohnsack@med.uni-goettingen.de.ORCID http://orcid.org/0000-0001-6035-4255
Markus T BohnsackDepartment of Molecular Biology, University Medical Centre Göttingen, Humboldtallee 23, 37073, Göttingen, Germany. markus.bohnsack@med.uni-goettingen.de.ORCID http://orcid.org/0000-0001-7063-5456
University of Göttingen · DENanoscale Microscopy and Molecular Physiology of the Brain Cluster of Excellence 171 — DFG Research Center 103 · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial matrix protein and active RNA methyltransferase responsible for installing m

Indexed as

AnticodonBase PairingCytosineGene Expression RegulationHEK293 CellsHumansMethylationMethyltransferasesMitochondriaNucleic Acid ConformationProtein BindingProtein BiosynthesisRNA, MitochondrialRNA, Transfer, SerRNA, Transfer, ThrSignal TransductionAnticodonCytosineMethyltransferasesMETTL8 protein, humanRNA, MitochondrialRNA, Transfer, SerRNA, Transfer, Thr

Identifiers

PMID35017528
PMCPMC8752778
OpenAlexW4205453386

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.