Evidence map›Paper›PMID 35017526›Full record

ArticleNature communications2022

C-type lectin receptor CLEC4A2 promotes tissue adaptation of macrophages and protects against atherosclerosis.

Inhye Park, Michael E Goddard, Jennifer E Cole, Natacha Zanin, Leo-Pekka Lyytikäinen, Terho Lehtimäki, Evangelos Andreakos, Marc Feldmann, Irina Udalova, Ignat Drozdov and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
4.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 54 citations in OpenAlex.

  1. Review
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  3. Review
  4. Review
  5. Review
  6. Review
  7. Article
  8. Research progress on macrophage regulation of atherosclerosis.Frontiers in cardiovascular medicine · 2026
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
  14. Review
  15. The C-type lectin receptor Dcir (Frontiers in immunology · 2025
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 3 countries.

Inhye ParkKennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-8084-139X
Michael E Goddard *Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Jennifer E Cole *Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-2247-9628
Natacha ZaninKennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Leo-Pekka LyytikäinenDepartment of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0002-7200-5455
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.ORCID http://orcid.org/0000-0002-2555-4427
Evangelos AndreakosBiomedical Research Foundation, Academy of Athens, Center for Clinical, Experimental Surgery and Translational Research, Athens, Greece.ORCID http://orcid.org/0000-0001-5536-1661
Marc FeldmannKennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.
Irina UdalovaKennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK.ORCID http://orcid.org/0000-0002-6716-2528
Ignat DrozdovBering Limited, London, TW2 6EA, UK.
Claudia MonacoKennedy Institute of Rheumatology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, UK. claudia.monaco@kennedy.ox.ac.uk.ORCID http://orcid.org/0000-0003-1985-4914
Nuffield Orthopaedic Centre · GBTampere University · FIAcademy of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Macrophages are integral to the pathogenesis of atherosclerosis, but the contribution of distinct macrophage subsets to disease remains poorly defined. Using single cell technologies and conditional ablation via a LysM

Indexed as

AnimalsApolipoproteins EAtherosclerosisBlood VesselsBone Marrow CellsCell DeathCell DifferentiationCell LineageCholesterolDisease Models, AnimalGene Expression RegulationHomeostasisHumansLectins, C-TypeMacrophage Colony-Stimulating FactorMacrophagesApolipoproteins ECholesterolCSF1 protein, mouseDcir protein, mouseLectins, C-TypeMacrophage Colony-Stimulating Factor

Identifiers

PMID35017526
PMCPMC8752790
OpenAlexW4205145157

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.