ArticleNature communications2022
Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 139 papers, 3 of them syntheses that pooled it.
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Who cites it
139 citing papers in PubMed, 3 syntheses or guidelines pooled it, 201 citations in OpenAlex.
- The emerging role of the meningeal lymphatic and glymphatic systems in migraine pathophysiology: a systematic review.The journal of headache and pain · 2026Pooled it
- Brain lymphatic drainage pathways, deep cervical lymphatic surgery, and current insights: A systematic review.The journal of prevention of Alzheimer's disease · 2026Pooled it
- Role of meningeal lymphatic vessels in brain homeostasis.Frontiers in immunology · 2025Pooled it
- Beyond FLAIR: PRISM (polarity-preserving real inversion solute mapping)-a new Frontier in real inversion recovery MRI for intracranial and sensory organ fluid assessment.Japanese journal of radiology · 2026Review
- Novel Therapeutic Insights Into Alzheimer's Disease: Glymphatic System and Meningeal Lymphatic Vessels.Aging cell · 2026Review
- Mapping Lymphatic Drainage from the Human Brain to the Head and Neck: Potential Surgical Implications for Dementia.Archives of plastic surgery · 2026Article
- Lymphatic Drainage of Cerebrospinal Fluid Using Lymph Node Seeker 64Cu-Labeled Gram-Negative Bacterial Extracellular Vesicles With Positron Emission Tomography (PET).Journal of extracellular vesicles · 2026Article
- Artificial intelligence-based segmentation of perisinusoidal tissue along the superior sagittal sinus in human brain magnetic resonance imaging.Neuroradiology · 2026Article
- Meningeal lymphatic dysfunction in Alzheimer's disease: molecular mechanisms, clinical implications, and future perspectives.Molecular neurodegeneration · 2026Review
- Postmortem Evidence of Lymphatic Vessels Located at the Boundary of Central and Peripheral Nervous Systems in the Cervical Spine.Cellular and molecular neurobiology · 2026Article
- Disrupted drainage in the aging brain: Meningeal lymphatic decline as a convergent axis of vulnerability.Neurobiology of aging · 2026Review
- [Research progress on vascular endothelial growth factor C in meningeal lymphatic vessel-mediated clearance of amyloid β-protein].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2026Review
- Reply to: Hyperintense FLAIR signal in the anterior cranial fossa.Nature communications · 2026Article
- Hyperintense FLAIR signal in the anterior cranial fossa.Nature communications · 2026Article
- The glymphatic system and glioblastoma.Brain : a journal of neurology · 2026Review
- Age-related development of meningeal lymphatic vessels in children assessed by 3D T2 FLAIR MRI.Scientific reports · 2026Article
- Cardiovascular ageing: hallmarks, signaling pathways, diseases and therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Impaired Glymphatic-Meningeal Lymphatic Function in Patients with Spontaneous Subarachnoid Hemorrhage.Translational stroke research · 2026Article
- Lymphatic topology reveals a novel intranodal lympho-venous shunt.The Journal of pathology · 2026Article
- The first total robotic-assisted lymphovenous anastomosis: prospects for innovation and future development.International journal of computer assisted radiology and surgery · 2026Article
79 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Meningeal lymphatic vessels have been described in animal studies, but limited comparable data is available in human studies. Here we show dural lymphatic structures along the dural venous sinuses in dorsal regions and along cranial nerves in the ventral regions in the human brain. 3D T2-Fluid Attenuated Inversion Recovery magnetic resonance imaging relies on internal signals of protein rich lymphatic fluid rather than contrast media and is used in the present study to visualize the major human dural lymphatic structures. Moreover we detect direct connections between lymphatic fluid channels along the cranial nerves and vascular structures and the cervical lymph nodes. We also identify age-related cervical lymph node atrophy and thickening of lymphatics channels in both dorsal and ventral regions, findings which reflect the reduced lymphatic output of the aged brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.