Evidence map›Paper›PMID 35017509›Full record

ArticleNature communications2022

Determinants of synapse diversity revealed by super-resolution quantal transmission and active zone imaging.

Zachary L Newman, Dariya Bakshinskaya, Ryan Schultz, Samuel J Kenny, Seonah Moon, Krisha Aghi, Cherise Stanley, Nadia Marnani, Rachel Li, Julia Bleier and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
20.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Active Zone Maturation Controls Presynaptic Output and Release Mode and Is Regulated by Neuronal Activity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Article
  10. Deficiency in transmitter release triggers homeostatic transcriptional changes that increase presynaptic excitability.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  11. Article
  12. Review
  13. The Discovery of Potential Repellent Compounds forInternational journal of molecular sciences · 2025
    Article
  14. Article
  15. Behavioral resilience via dynamic circuit firing homeostasis.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  16. Review
  17. Article
  18. Article
  19. Synapse-specific catecholaminergic modulation of neuronal glutamate release.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Zachary L NewmanDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, 94720, USA.
Dariya BakshinskayaHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, 94720, USA.
Ryan SchultzHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, 94720, USA.
Samuel J KennyDepartment of Chemistry, University of California, Berkeley, CA, 94720, USA.
Seonah MoonDepartment of Chemistry, University of California, Berkeley, CA, 94720, USA.
Krisha AghiHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-9087-6641
Cherise StanleyDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, 94720, USA.
Nadia MarnaniDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, 94720, USA.
Rachel LiDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, 94720, USA.
Julia BleierHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, 94720, USA.
Ke XuDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, 94720, USA.ORCID http://orcid.org/0000-0002-2788-194X
Ehud Y IsacoffDepartment of Molecular and Cell Biology, University of California Berkeley, Berkeley, CA, 94720, USA. ehud@berkeley.edu.ORCID http://orcid.org/0000-0003-4775-9359
University of California, Berkeley · USLawrence Berkeley National Laboratory · US

Funding

Neuroscience Training Program at UC BerkeleyT32NS095939 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI BATEUP, HELEN S. · 2016 to 2025
$6.3M
Novel tools for cell-specific imaging of functional connectivity and circuit operationsU01MH109069 · NIMH · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2015 to 2017
$2.2M
Synaptic to circuit homeostasis in the Drosophila locomotor systemR01NS107506 · NINDS · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2019 to 2023
$1.6M
Optical Stimulation MicroscopeS10RR028971 · NCRR · UNIVERSITY OF CALIFORNIA BERKELEY · PI ISACOFF, EHUD · 2011 to 2011
$596k
NCRR NIH HHS S10 RR028971NIMH NIH HHS U01 MH109069NINDS NIH HHS R01 NS107506NINDS NIH HHS T32 NS095939
6 · The paper itself

Abstract

Neural circuit function depends on the pattern of synaptic connections between neurons and the strength of those connections. Synaptic strength is determined by both postsynaptic sensitivity to neurotransmitter and the presynaptic probability of action potential evoked transmitter release (P

Indexed as

Diagnostic ImagingAnimalsDrosophilaFemaleNeuromuscular JunctionNeurotransmitter AgentsOptical ImagingPresynaptic TerminalsSynapsesSynaptic TransmissionNeurotransmitter Agents

Identifiers

PMID35017509
PMCPMC8752601
OpenAlexW4205262694

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.