Evidence map›Paper›PMID 35017442›Full record

ArticleNeural regeneration research2022

Efficacy and safety of transcutaneous auricular vagus nerve stimulation combined with conventional rehabilitation training in acute stroke patients: a randomized controlled trial conducted for 1 year involving 60 patients.

Jia-Ni Li, Chen-Chen Xie, Chang-Qing Li, Gui-Fang Zhang, Hao Tang, Chuan-Na Jin, Jing-Xi Ma, Lan Wen, Ke-Ming Zhang, Ling-Chuan Niu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 6 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 6 syntheses or guidelines pooled it, 67 citations in OpenAlex.

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  19. Clinical Effectiveness of Multimodal Exercise Combined With Supportive Music and Imagery in the Management of Poststroke Mood Disorders.The Journal of neuroscience nursing : journal of the American Association of Neuroscience Nurses · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Jia-Ni LiDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chen-Chen XieDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chang-Qing LiDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Gui-Fang ZhangDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Hao TangDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chuan-Na JinDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jing-Xi MaDepartment of Neurology, Chongqing General Hospital, University of Chinese Academy of Sciences; Chongqing Key Laboratory of Neurodegenerative Diseases, Chongqing, China.
Lan WenDepartment of Neurology, West China Hospital of Sichuan University, Chengdu, Sichuan Province, China.
Ke-Ming ZhangClinical College, Chongqing Medical and Pharmaceutical College, Chongqing, China.
Ling-Chuan NiuDepartment of Neurology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Dalian Medical University · CNSecond Affiliated Hospital of Chongqing Medical University · CNChongqing Medical and Pharmaceutical College · CNChongqing Medical University · CNUniversity of Chinese Academy of Sciences · CNWest China Hospital of Sichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transcutaneous auricular vagus nerve stimulation (ta-VNS) is a novel noninvasive treat-ment for stroke that directly stimulates the peripheral auricular branch of the vagus nerve. There have been recent reports that ta-VNS combined with conventional rehabilitation training promotes the recovery of neurological function of patients with acute stroke. However, these were small-sample-sized studies on the recovery of neurological function in patients after percutaneous vagus nerve stimulation in the subacute and chronic phases after stroke. This double-blinded randomized controlled trial involved 60 acute ischemic or hemorrhagic stroke patients aged 18-80 years who received treatment in the Second Affiliated Hospital of Chongqing Medical University. The subjects were randomly assigned to receive ta-VNS or sham ta-VNS combined with conventional rehabilitation training. The follow-up results over 1 year revealed that ta-VNS combined with conventional rehabilitation training greatly improved the recovery of motor and sensory functions and emotional responses compared with sham ta-VNS combined with conventional rehabilitation training. There were no obvious side effects. These findings suggest that ta-VNS combined with conventional rehabilitation training for the treatment of acute ischemic or hemorrhagic stroke patients is safe and effective.

Indexed as

activity of daily livingearly stage treatmentemotional disorderlimb dysfunctionneural regenerationrandomized controlled clinical trialrehabilitationsafety of treatmentstroketranscutaneous auricular-vagus nerve stimulation

Identifiers

PMID35017442
PMCPMC8820701
OpenAlexW4200562389

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.