Evidence map›Paper›PMID 35017441›Full record

ArticleNeural regeneration research2022

Mice lacking perforin have improved regeneration of the injured femoral nerve.

Igor Jakovcevski, Monika von Düring, David Lutz, Maja Vulović, Mohammad Hamad, Gebhard Reiss, Eckart Förster, Melitta Schachner

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neural regeneration research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Melatonin signalling in Schwann cells during neuroregeneration.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Igor JakovcevskiInstitut für Anatomie und Klinische Morphologie, Universität Witten/Herdecke, Witten, Germany.
Monika von DüringDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Bochum, Germany.
David LutzDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Bochum, Germany.
Maja VulovićDepartment of Anatomy, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia.
Mohammad HamadInstitut für Anatomie und Klinische Morphologie, Universität Witten/Herdecke, Witten, Germany.
Gebhard ReissInstitut für Anatomie und Klinische Morphologie, Universität Witten/Herdecke, Witten, Germany.
Eckart FörsterDepartment of Neuroanatomy and Molecular Brain Research, Ruhr University Bochum, Bochum, Germany.
Melitta SchachnerKeck Center for Collaborative Neuroscience and Department of Cell Biology and Neuroscience, Rutgers University, Piscataway, NJ, USA.
Ruhr University Bochum · DEWitten/Herdecke University · DERutgers, The State University of New Jersey · USUniversity of Kragujevac · RS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The role that the immune system plays after injury of the peripheral nervous system is still not completely understood. Perforin, a natural killer cell- and T-lymphocyte-derived enzyme that mediates cytotoxicity, plays important roles in autoimmune diseases, infections and central nervous system trauma, such as spinal cord injury. To dissect the roles of this single component of the immune response to injury, we tested regeneration after femoral nerve injury in perforin-deficient (Pfp

Indexed as

blood-nerve barrierfemoral nerve injurylocomotor recoverylymphocytesmyelinationNK-cellsperforinreinnervation

Identifiers

PMID35017441
PMCPMC8820721
OpenAlexW4200016622

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.